Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network.
Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network.
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DOI：
10.1523/jneurosci.2021-06.2006
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发表时间：
2006-09-13
期刊：
影响因子：
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通讯作者：
Dolan RJ
中科院分区：
文献类型：
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作者：
Kalisch R;Korenfeld E;Stephan KE;Weiskopf N;Seymour B;Dolan RJ
在恐惧消退过程中，动物了解到条件刺激 (CS) 不再预测它之前与之相关的有害刺激 [非条件刺激 (UCS)]，从而导致条件反应 (CR) 的抑制。消退创建了一个新的 CS-noUCS 记忆痕迹，与最初的恐惧 (CS-UCS) 记忆竞争。消退记忆的回忆以及随后的 CS 遭遇中的 CR 抑制是通过消退训练期间存在的情境刺激来促进的。与来自动物研究的理论预测一致，我们表明，在灭绝之后，CS诱发的人类腹内侧前额叶皮层（VMPFC）和海马体的参与是环境依赖性的，在灭绝环境中表达，而不是在调节环境中。同样，VMPFC 和海马活动之间的正相关性也依赖于消退环境。因此，VMPFC-海马网络提供了人类灭绝记忆的情境依赖性回忆，这与海马赋予 VMPFC 情境依赖性的观点一致。
In fear extinction, an animal learns that a conditioned stimulus (CS) no longer predicts a noxious stimulus [unconditioned stimulus (UCS)] to which it had previously been associated, leading to inhibition of the conditioned response (CR). Extinction creates a new CS–noUCS memory trace, competing with the initial fear (CS–UCS) memory. Recall of extinction memory and, hence, CR inhibition at later CS encounters is facilitated by contextual stimuli present during extinction training. In line with theoretical predictions derived from animal studies, we show that, after extinction, a CS-evoked engagement of human ventromedial prefrontal cortex (VMPFC) and hippocampus is context dependent, being expressed in an extinction, but not a conditioning, context. Likewise, a positive correlation between VMPFC and hippocampal activity is extinction context dependent. Thus, a VMPFC–hippocampal network provides for context-dependent recall of human extinction memory, consistent with a view that hippocampus confers context dependence on VMPFC.