EFFECT OF AGE ON CREATININE CLEARANCE IN MEN - CROSS-SECTIONAL AND LONGITUDINAL STUDY
EFFECT OF AGE ON CREATININE CLEARANCE IN MEN - CROSS-SECTIONAL AND LONGITUDINAL STUDY
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DOI：
10.1093/geronj/31.2.155
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发表时间：
1976-01-01
期刊：
影响因子：
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通讯作者：
SHOCK, NW
中科院分区：
文献类型：
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作者：
ROWE, JW;ANDRES, R;SHOCK, NW
对巴尔的摩纵向研究的884名受试者进行标准24小时真实肌酐清除率测定。在临床数据的基础上，受试者被划分为可能改变肾小球滤过率的特定疾病或药物的类别。未包括在这些类别中的受试者被认为是正常的（N = 548）。在正常情况下，10岁年龄组的横断面分析显示清除率从30岁时的140 ml/min / 1.73 m2逐渐线性下降到80岁时的97 ml/min。在293名正常受试者中，每隔12-18个月获得3次或更多的连续清除。这些纵向数据显示，随着年龄的增长，肌酐清除率下降的速度加快。在这项研究中，肌酐清除率随着年龄的增长而下降，这代表了真正的肾脏衰老，而不是继发于老年人中越来越普遍的疾病。从这些数据构建的nomogram为肌酐清除率提供了规范的年龄校正标准。
Standard true 24-h creatinine clearance determinations were performed on 884 subjects of the Baltimore Longitudinal Study. On the basis of clinical data, subjects were placed in categories indicating the presence of specific diseases or medications which might alter glomerular filtration rate. Subjects not included in these categories were considered normal (N = 548). In the normals, cross-sectional analysis by 10-yr age groups showed a progressive linear decline in clearance from 140 ml/min per 1.73 m2 at age 30 to 97 at age 80. Three or more serial clearances were obtained at 12-18 mo. intervals on 293 normal subjects. These longitudinal data showed an acceleration of the rate of decline in creatinine clearance with advancing age. The decrease in creatinine clearance with age seen in this study represents true renal aging and is not secondary to diseases which become increasingly prevalent in the elderly. A nomogram constructed from these data provides normative age-corrected standards for creatinine clearance.