Breath condensate pH in children with cystic fibrosis and asthma - A new noninvasive marker of airway inflammation?
Breath condensate pH in children with cystic fibrosis and asthma - A new noninvasive marker of airway inflammation?
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DOI：
10.1378/chest.125.6.2005
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发表时间：
2004-06-01
期刊：
影响因子：
9.6
通讯作者：
Kharitonov, SA
中科院分区：
文献类型：
--
作者：
Carpagnano, GE;Barnes, PJ;Kharitonov, SA
研究目标：气道炎症的无创评估和监测对于呼吸系统疾病可能很重要。呼出气冷凝液 (EBC) 的 pH 值是一个很有前景的标记。虽然已经测量了患有炎症性气道疾病的成人 EBC 的 pH 值，但没有研究在儿童中测量过这一点。 设计：本研究旨在评估患有囊性纤维化 (CF) 和哮喘的儿童 EBC 中的 pH 值是否发生变化，并尝试确定 pH 值是否可以用作气道炎症的标志物。此外，还研究了 EBC pH、疾病严重程度和氧化应激之间的关系。 患者和方法：我们研究了 20 名 CF 儿童（平均年龄 [+/- SEM] 7 +/- 3 岁）、20 名哮喘儿童（平均年龄 7 2 岁）和 15 名年龄匹配的健康儿童（平均年龄 7 2 岁）。使用 pH 计测量 EBC 的 pH 值。 测量和结果：与对照受试者相比，CF 和哮喘儿童的 EBC 中观察到较低的 pH 值（平均 pH 值分别为 7.23 +/- 0.03 和 7.42 +/- 0.01 vs 7.85 +/- 0.02）。此外，还发现了 EBC pH、哮喘严重程度和 CF 感染性恶化之间的关系。呼气 pH 值与呼出白三烯 B-4 浓度呈负相关（r = -0.5；p < 0.005）。结论：我们得出结论，EBC pH 的测量可能有助于评估哮喘合并 CF 儿童的气道炎症。
Study objectives: The noninvasive assessment and monitoring of airway inflammation could be important in respiratory disease. The pH of exhaled breath condensate (EBC) is a promising marker. Although pH has been measured in the EBC of adults with inflammatory airway diseases, no study has measured this in children.Design: This study aimed to assess whether there is a change in pH in the EBC of children with cystic fibrosis (CF) and asthma, and to try to determine whether pH could be used as a marker of airway inflammation. Furthermore, the relationships among EBC pH, severity of disease, and oxidative stress were studied.Patients and methods: We studied 20 children with CF (mean [+/- SEM] age, 7 +/- 3 years), 20 children with asthma (mean age, 7 2 years), and 15 age-matched healthy children (mean age, 7 2 years). The pH of EBC was measured using a pH meter.Measurements and results: Lower pH values were observed in the EBC of children with CF and asthma compared to control subjects (mean pH, 7.23 +/- 0.03 and 7.42 +/- 0.01 vs 7.85 +/- 0.02, respectively). Furthermore, relationships among EBC pH, severity of asthma, and the presence of an infective exacerbation of CF was found. There was a negative correlation between exhaled pH and exhaled leukotriene B-4 concentrations (r = -0.5; p < 0.005).Conclusion: We conclude that the measurement of EBC pH may be useful in the evaluation of airway inflammation in children with asthma and CF.