Quantification of reduced macular pigment optical density in the central retina in macular telangiectasia type 2
Quantification of reduced macular pigment optical density in the central retina in macular telangiectasia type 2
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DOI：
10.1016/j.exer.2009.02.006
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发表时间：
2009-06-01
影响因子：
3.4
通讯作者：
Berendschot, Tos T. J. M.
中科院分区：
文献类型：
--
作者：
Issa, Peter Charbel;van der Veen, Rob L. P.;Berendschot, Tos T. J. M.
最近，一个独特的分布，即减少黄斑色素光密度（MPOD）在中央视网膜与周围的环状结构的保留MPOD在约6度偏心被认为是一种常见的发现，在黄斑毛细血管扩张症（MacTel）2型。为了量化这种减少的MPOD，通过眼底反射计和两个波长的眼底自发荧光（FAF：在488 nm和514 nm）研究了14名MacTel 2型患者的28只眼睛。眼底反射仪显示中央4度偏心率内的MPOD减少，这在小凹的颞部最不存在。在6度时，MP密度与正常值没有差异。两个波长的FAF符合这些发现。眼底反射仪也允许单独测定叶黄素和玉米黄质。患有MacTel 2型的患者表现出预防性的高玉米黄质减少。这项研究表明，在MacTel 2型中，可能无法在中央视网膜中积累MP。该疾病可作为进一步研究视网膜疾病中MP分布异常和阐明MP沉积在视网膜中的机制的模型。(C)2009爱思唯尔有限公司版权所有。
Recently, a unique distribution, namely a reduction of macular pigment optical density (MPOD) within the central retina with a surrounding ring-like structure of preserved MPOD at about 6 degrees eccentricity was suggested to be a common finding in macular telangiectasia (MacTel) type 2. In order to quantify this reduced MPOD, 28 eyes of 14 patients with MacTel type 2 were investigated by fundus reflectometry, and two wavelengths fundus autofluorescence (FAF: at 488 nm and 514 nm). Fundus reflectometry showed a reduced MPOD within the central 4 degrees eccentricity that was most absent temporal to the foveola. At 6 degrees, MP density was not different from normative values. Two wavelengths FAF was in accordance with these findings. Fundus reflectometry also allowed separate determination of lutein and zeaxanthin. The patients with MacTel type 2 showed a disproportionally high zeaxanthin reduction. The study suggests that in MacTel type 2, there might be an inability to accumulate MP in the central retina. This disease might serve as a model to further study abnormalities of MP distribution in retinal disorders and to elucidate the mechanisms of MP deposition in the retina. (C) 2009 Elsevier Ltd. All rights reserved.