Quorum sensing and biofilm formation in Streptococcal infections
Quorum sensing and biofilm formation in Streptococcal infections
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DOI：
10.1172/jci200320430
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发表时间：
2003-12-01
影响因子：
15.9
通讯作者：
Ellen, RP
中科院分区：
文献类型：
--
作者：
Cvitkovitch, DG;Liu, YH;Ellen, RP
链球菌属细菌的成员负责在人类中引起各种感染。许多链球菌使用群体感应系统来调节几个生理特性，包括结合外源DNA、耐受酸、形成生物膜和变得毒力的能力。这些群体感应系统主要由小的可溶信号肽组成，通过组氨酸激酶/反应调节因子对被邻近细胞检测到。
Members of the bacterial genus Streptococcus are responsible for causing a wide variety of infections in humans. Many Streptococci use quorum-sensing systems to regulate several physiological properties, including the ability to incorporate foreign DNA, tolerate acid, form biofilms, and become virulent. These quorum-sensing systems are primarily made of small soluble signal peptides that are detected by neighboring cells via a histidine kinase/response regulator pair.