Acute Effects of Intraocular Pressure-Induced Changes in Schlemm's Canal Morphology on Outflow Facility in Healthy Human Eyes
Acute Effects of Intraocular Pressure-Induced Changes in Schlemm's Canal Morphology on Outflow Facility in Healthy Human Eyes
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DOI：
10.1167/iovs.61.8.36
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发表时间：
2020-07-01
影响因子：
4.4
通讯作者：
Wang, Junming
中科院分区：
文献类型：
--
作者：
Chen, Wei;Hu, Tian;Wang, Junming
目的。方法：用无创眼压眼压计(OPT)测量25名健康志愿者的眼压(IOP)衰减值，在固定外力(0.15N)作用于颞下眼睑，每隔10秒，持续4分钟，休息30分钟后，测量眼压(IOP)衰减值。分别于术前(基线)、术后即刻(T0)和术后1分钟(T1、T2、T3、T4)测量Schlemm‘s管侧位图像和眼压。C值按不同眼压计算。结果在40 mm Hg和20 mm Hg时，最大眼压的平均C-0分别为0.020±0.017亩L/分/毫米汞柱、0.018±0.0071和0.058±0.0146亩L/分/毫米汞。C与眼压呈非线性相关(R2=0.945)。瘢痕面积分别为5440+/-3140.82、3947.6+/-2246.8和5375.7+/-2662.7亩(2)。SC冠径从基线(33.02±11.3 mm)显著减小到T0(26.6±9.37 mm)，在T4(32.3±9.53 mm)恢复。瘢痕与眼压始终呈显著正相关(R-2=0.9944；P<；0.001)。从T0到T4，C0与瘢痕和眼压的变化显著相关。结论Schlemm管的大小是眼压依赖的机械力的原因，这些变化似乎直接影响流出设施。
PURPOSE. To estimate the outflow facility coefficient (C) as a function of Schlemm's canal cross-sectional area (SCAR) in healthy subjects using noninvasive oculopression tonometry (OPT).METHODS. In 25 healthy volunteers, intraocular pressure (IOP) decay values were recorded by a ophthalmodynamometer, with a fixed external force (0.15 N) on the inferior-temporal eyelid, every 10 seconds, for four minutes, and again after a 30-minute rest. Schlemm's canal profile images and IOP were obtained pre-procedurally (baseline), immediately (T0), and at 1-minute intervals post-procedurally (T1, T2, T3, and T4). C was calculated for different IOPs. The SCAR, coronal, and the meridional diameter of Schlemm's canal were calculated.RESULTS. Mean C-0 for the maximum IOP was 0.020 +/- 0.017 mu L/min/mm Hg; mean C was 0.018 +/- 0.0071 and 0.058 +/- 0.0146 mu L/min/mm Hg at 40 and 20 mm Hg, respectively. C was nonlinearly dependent on the IOP (R-2 = 0.945). The SCAR was 5440 +/- 3140.82, 3947.6 +/- 2246.8, and 5375.7 +/- 2662.7 mu m(2) at baseline, T0, and T4, respectively. The coronal diameter of SC decreased significantly from the baseline (33.02 +/- 11.3 mu m) to T0 (26.6 +/- 9.37 mu m) and recovered at T4 (32.3 +/- 9.53 mu m). The SCAR and IOP correlated significantly throughout (R-2 = 0.9944; P < 0.001). C0 significantly correlated with the SCAR at baseline and with changes in the SCAR and IOP from T0 to T4.CONCLUSIONS. Schlemm's canal dimensions are responsible for the IOP-dependent mechanical forces, and these changes appear to directly affect outflow facility.