Reflections on the Histopathology of Tumor-Infiltrating Lymphocytes in Melanoma and the Host Immune Response.
Reflections on the Histopathology of Tumor-Infiltrating Lymphocytes in Melanoma and the Host Immune Response.
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DOI：
10.1158/2326-6066.cir-15-0143
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发表时间：
2015-08
影响因子：
10.1
通讯作者：
Mulé JJ
中科院分区：
文献类型：
--
作者：
Mihm MC Jr;Mulé JJ
在过去的五十年中，淋巴细胞在宿主对肿瘤的免疫应答中的作用已被证明是疾病预后的关键组成部分，至少在一些患者中是如此。此外，淋巴细胞的异质性已被记录，包括抑制免疫应答的调节性T细胞的存在。随着淋巴细胞的功能在抗肿瘤免疫方面变得更好地定义，淋巴细胞上的特异性靶点已经被发现。对免疫检查点的作用的认识也导致了治疗方法，其说明了阻断抗肿瘤免疫应答的负调节剂的有效性。在这篇免疫学硕士论文中，我们追溯了我们对肿瘤浸润淋巴细胞的理解的演变，并讨论了它们在黑色素瘤预后中的作用，从它们存在的最基本观察到它们功能的最新操纵，结果是改善了宿主对肿瘤的反应。
In the last five decades the role for lymphocytes in host immune response to tumors has been shown, at least in some patients, to be a critical component in disease prognosis. Also, the heterogeneity of lymphocytes has been documented including the existence of regulatory T cells that suppress the immune response. As the functions of lymphocytes have become better defined in terms of antitumor immunity, specific targets on lymphocytes have been uncovered. The appreciation of the role of immune-checkpoints has also led to therapeutic approaches that illustrate the effectiveness of blocking negative regulators of the antitumor immune response. In this Masters of Immunology article, we trace the evolution of our understanding of tumor-infiltrating lymphocytes and discuss their role in melanoma prognosis from the very basic observation of their existence to the latest manipulation of their functions with the result of improvement of the host response against the tumor.