Zebrafish Syndromic Albinism Models as Tools for Understanding and Treating Pigment Cell Disease in Humans.
Zebrafish Syndromic Albinism Models as Tools for Understanding and Treating Pigment Cell Disease in Humans.
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DOI：
10.3390/cancers14071752
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发表时间：
2022-03-30
期刊：
影响因子：
5.2
通讯作者：
Cooper CD
中科院分区：
文献类型：
--
作者：
Neuffer SJ;Cooper CD
斑马鱼（Danio rerio）是一种新兴的模型，用于研究许多疾病，包括起源于黑色色素细胞，黑色素细胞的疾病。在这篇关于黑素细胞的文献综述中，我们讨论了与理解不同形式的白化病相关的黑素细胞生物学的当前知识，以及斑马鱼模型系统在寻找新机制和治疗方面的潜力。黑色素是一种通过吸收多余的能量来保护DNA免受紫外线伤害的色素。黑色素是在黑色素生成过程中产生的。当黑色素生成发生改变时，就会导致白化病等疾病。白化病会增加患皮肤癌的风险。相反，黑素细胞（黑素细胞）的发育途径可能被错误调节，导致黑素细胞过度生长，导致黑色素瘤（黑素细胞的癌症）。斑马鱼是一种新兴的模式生物，用于研究色素疾病，因为它们具有高繁殖力，受精后24小时黑色素细胞（哺乳动物的黑色素细胞）中可见的黑色素发育，以及保守的黑色素形成途径。本文综述了斑马鱼黑色素细胞和哺乳动物黑色素细胞的保守发育途径。此外，我们总结了在理解色素细胞疾病方面取得的进展，以及支持利用斑马鱼寻找白化病新治疗方案的强大潜力的证据。
Zebrafish (Danio rerio) is an emerging model for studying many diseases, including disorders originating in black pigment cells, melanocytes. In this review of the melanocyte literature, we discuss the current knowledge of melanocyte biology relevant to understanding different forms of albinism and the potential of the zebrafish model system for finding novel mechanisms and treatments. Melanin is the pigment that protects DNA from ultraviolet (UV) damage by absorbing excess energy. Melanin is produced in a process called melanogenesis. When melanogenesis is altered, diseases such as albinism result. Albinism can result in an increased skin cancer risk. Conversely, black pigment cell (melanocyte) development pathways can be misregulated, causing excessive melanocyte growth that leads to melanoma (cancer of melanocytes). Zebrafish is an emerging model organism used to study pigment disorders due to their high fecundity, visible melanin development in melanophores (melanocytes in mammals) from 24 h post-fertilization, and conserved melanogenesis pathways. Here, we reviewed the conserved developmental pathways in zebrafish melanophores and mammalian melanocytes. Additionally, we summarized the progress made in understanding pigment cell disease and evidence supporting the strong potential for using zebrafish to find novel treatment options for albinism.
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影响因子：
2.7
作者：
D'Agati G;Beltre R;Sessa A;Burger A;Zhou Y;Mosimann C;White RM
通讯作者：
White RM
影响因子：
64.5
作者：
Cui, Rutao;Widlund, Hans R.;Fisher, David E.
通讯作者：
Fisher, David E.
斑马鱼游泳鳔表面活性剂系统的发育和溶酶体相关细胞器的生物发生受 BLOS1 调节。
影响因子：
3.3
作者：
Chen, Tianbing;Song, Guili;Huang, Kaiyao
通讯作者：
Huang, Kaiyao
影响因子：
3.7
作者：
Clancey, Lauren F.;Beirl, Alisha J.;Cooper, Cynthia D.
通讯作者：
Cooper, Cynthia D.
影响因子：
3.5
作者：
Barbosa, MDFS;Barrat, FJ;Kingsmore, SF
通讯作者：
Kingsmore, SF