Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses.
Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses.
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DOI：
10.1084/jem.143.6.1391
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发表时间：
1976-06-01
期刊：
影响因子：
--
通讯作者：
Boyse EA
中科院分区：
文献类型：
--
作者：
Cantor H;Shen FW;Boyse EA
Lyl亚类细胞在绵羊红细胞（SRBC）的原发性和继发性反应中产生辅助活性。相比之下，在SRBC启动后，Ly-2+亚类细胞，特别是Ly23细胞具有抑制活性。ly23介导的抑制程度与用于引物的抗原（SRBC）的数量成正比。Ly23细胞的抑制是特异性的，因为来自srbc启动动物的Ly23细胞不会抑制对马红细胞的反应，反之亦然。因此，细胞毒性和特异性抑制功能都是由一种亚类T细胞介导的，暂时称为TCS，它可以通过其Ly表型与辅助性T细胞（TH）区分开来。杀伤和抑制是单一Ly23亚类在功能上相互关联的特性，还是Ly23种群由两个表面表型尚不能通过免疫遗传学标准区分的亚类组成，仍有待确定。
Cells of the Lyl subclass generate helper activity in both primary and secondary responses to sheep erythrocytes (SRBC). In contrast, after priming with SRBC, cells of the Ly-2+ subclasses, in particular Ly23 cells, have suppressive activity. The degree of Ly23-mediated suppression is directly proportional to the amount of antigen (SRBC) used for priming. Suppression by Ly23 cells is specific, because Ly23 cells from SRBC-primed animals do not suppress the response to horse erythrocytes, and vice versa. Thus, both cytotoxic and specific suppressor functions are mediated by T cells of a subclass, provisionally designated TCS, which can be distinguished from helper T cells (TH), by their Ly phenotypes. It remains to be determined whether killing and suppression are functionally interrelated properties of a single Ly23 subclass, or whether the Ly23 population comprises two subclasses whose surface phenotypes are not yet distinguishable by immunogenetic criteria.