Duration of retinogenesis: its relationship to retinal organization in two cricetine rodents.
Duration of retinogenesis: its relationship to retinal organization in two cricetine rodents.
复制标题
视网膜发生的持续时间：其与两种仓鼠啮齿动物视网膜组织的关系。
DOI：
10.1002/cne.902850202
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Finlay,BL
中科院分区：
文献类型：
--
作者：
Wikler,KC;Perez,G;Finlay,BL
长爪沙鼠（Meriones unguiculatus）相对于其他啮齿类动物具有较长的发育期。我们已经通过比较沙鼠视网膜中神经发生的持续时间和地形图与快速发育的密切相关物种叙利亚仓鼠（Mesocricetus auratus）的神经发生的持续时间和地形图，探索了这种相对较长的成熟期对视网膜细胞数量和地形图的影响（Sengelaub等人：J. Comp.神经元246：527-543，1986）。对胸腺嘧啶标记的视网膜的分析表明，沙鼠视网膜神经节细胞层的细胞至少在胚胎期12天内产生，是仓鼠的两倍。沙鼠视网膜神经节细胞层的细胞损失期至少持续14天，是仓鼠的两倍多。沙鼠视网膜产生的视网膜神经节细胞和位移无长突细胞的中心到周边的梯度，而没有这样的梯度是明显的仓鼠视网膜。我们的结论是，沙鼠较长的发育期与（1）较长的神经发生期导致更多的视网膜细胞数量，（2）空间梯度的表达在神经发生，（3）在成熟时更大的眼睛。最后两个因素，在一定程度上，可能与高度分化的中央区和视觉条纹在视网膜的啮齿动物。
The Mongolian gerbil (Meriones unguiculatus) has a prolonged period of development relative to other muroid rodents. We have explored the consequences of this relatively long period of maturation on retinal cell number and topography by comparing the duration and topography of neurogenesis in the gerbil retina with that of a closely related species which develops rapidly, the Syrian hamster (Mesocricetus auratus)(Sengelaub et al.: J. Comp. Neurol. 246: 527–543, 1986). An analysis of thymidine-labeled retinas indicate that cells destined for the gerbil retinal ganglion cell layer are generated for at least 12 embryonic days, twice the duration in the hamster. The period of cell loss in the gerbil retinal ganglion cell layer extends for at least 14 postnatal days, more than twice as long as in the hamster. The gerbil retina is generated in a center-to-periphery gradient for both retinal ganglion cells and displaced amacrine cells, while no such gradients are evident in the hamster retina. We conclude that the longer developmental period of the gerbil is associated with (1) a longer period of neurogenesis resulting in greater retinal cell number,(2) the expression of spatial gradients in neurogenesis, and (3) a larger eye at maturity. The last two factors, in part, may be related to the development of a highly differentiated area centralis and visual streak in the retina of this rodent.