AsMamDB: an alternative splice database of mammals
AsMamDB: an alternative splice database of mammals
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DOI：
10.1093/nar/29.1.260
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发表时间：
2001-01-01
影响因子：
14.9
通讯作者：
Li, YD
中科院分区：
文献类型：
--
作者：
Ji, HK;Zhou, Q;Li, YD
AsMamDB数据库的目的是促进哺乳动物可变剪接基因的系统研究。AsMamDB 1.0版包含1563个人类、小鼠和大鼠的可变剪接基因，每个基因与一组核苷酸序列相关。AsMamDB提供的主要信息包括基因选择性剪接模式、基因结构、在染色体中的位置、基因产物和它们表达的组织。选择性剪接模式由多种基因转录本的多重比对和它们的拓扑结构图表示。基因结构由外显子、内含子和各种调控元件的分布来说明。现有数据库中有4204个DNA、3977个mRNA、8989个CDS和126931个EST。超过130 000个GenBank条目被覆盖，4443个MEDLINE记录被链接。DNA、mRNA、外显子、内含子和相关调控元件序列以FASTA格式提供。更多的信息可以通过使用基于网络的多对齐工具Asalign和各种类别列表来获得。AsMamDB可以在http://166.111.30.65/ ASMAMDB.html上访问。
The objective of database AsMamDB is to facilitate the systematic study of alternatively spliced genes of mammals. Version 1.0 of AsMamDB contains 1563 alternatively spliced genes of human, mouse and rat, each associated with a cluster of nucleotide sequences. The main information provided by AsMamDB includes gene alternative splicing patterns, gene structures, locations in chromosomes, products of genes and tissues where they express. Alternative splicing patterns are represented by multiple alignments of various gene transcripts and by graphs of their topological structures. Gene structures are illustrated by exon, intron and various regulatory elements distributions. There are 4204 DNAs, 3977 mRNAs, 8989 CDSs and 126 931 ESTs in the current database. More than 130 000 GenBank entries are covered and 4443 MEDLINE records are linked. DNA, mRNA, exon, intron and relevant regulatory element sequences are provided in FASTA format. More information can be obtained by using the web-based multiple alignment tool Asalign and various category lists. AsMamDB can be accessed at http://166.111.30.65/ ASMAMDB.html.