Rebound Hypoglycemia and Hyperglycemia in Type 1 Diabetes.
Rebound Hypoglycemia and Hyperglycemia in Type 1 Diabetes.
复制标题
1 型糖尿病中的低血糖和高血糖反弹。
DOI：
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发表时间：
2023
影响因子：
5
通讯作者：
B. Bibby
中科院分区：
文献类型：
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作者：
K. Hansen;B. Bibby
目标管理系统
目的是调查低血糖和高血糖反弹事件，并描述它们与其他血糖指标的关系。
方法
下载了 159 名 1 型糖尿病患者 90 天的间歇扫描连续血糖监测数据。低血糖事件定义为至少两次 15 分钟内血糖<3.9 mmol/l。反弹性低血糖 (Rhypo) 是指在 120 分钟内血糖 >10.0 mmol/l 之前发生的低血糖事件，反弹性高血糖 (Rhyper) 是指发生低血糖后 120 分钟内血糖 >10.0 mmol/l 的事件。
结果
总共确定了 10 977 起低血糖事件，其中 3232 起 (29%) 为 Rhypo，3653 起 (33%) 为 Rhyper，对应的中位频率为每人/14 天 10.1、2.5 和 3.0 起事件。对于 1267 个（12%）的病例，Rhypo 和 Rhyper 共存。在 Rhypo 之前，平均峰值葡萄糖为 13.0 ± 1.6 mmol/l； Rhyper 中为 12.8 ± 1.1 mmol/l。 Rhyper 的频率与 Rhypo (Spearman's rho 0.84)、葡萄糖变异系数 (0.78) 和低于范围的时间 (0.69) 显着相关 (P < .001)，但与高于范围的时间不相关 (0.12，P = .13)。
结论
Rhyper 和 Rhypo 之间的强相关性表明个体行为特征倾向于强化葡萄糖偏移校正。
AIMS
The aim was to investigate rebound hypoglycemic and hyperglycemic events, and describe their relation to other glycemic metrics.
METHODS
Data from intermittently scanned continuous glucose monitoring were downloaded for 90 days for 159 persons with type 1 diabetes. A hypoglycemic event was defined as glucose <3.9 mmol/l for at least two 15-minute periods. Rebound hypoglycemia (Rhypo) was a hypoglycemic event preceded by glucose >10.0 mmol/l within 120 minutes and rebound hyperglycemia (Rhyper) was hypoglycemia followed by glucose >10.0 mmol/l within 120 minutes.
RESULTS
A total of 10 977 hypoglycemic events were identified of which 3232 (29%) were Rhypo and 3653 (33%) were Rhyper, corresponding to a median frequency of 10.1, 2.5, and 3.0 events per person/14 days. For 1267 (12%) of the cases, Rhypo and Rhyper coexisted. The mean peak glucose was 13.0 ± 1.6 mmol/l before Rhypo; 12.8 ± 1.1 mmol/l in Rhyper. The frequency of Rhyper was significantly (P < .001) correlated with Rhypo (Spearman's rho 0.84), glucose coefficient of variation (0.78), and time below range (0.69) but not with time above range (0.12, P = .13).
CONCLUSIONS
The strong correlation between Rhyper and Rhypo suggests an individual behavioral characteristic toward intensive correction of glucose excursions.