Pancratistatin: A natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis
Pancratistatin: A natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis
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DOI：
10.1007/s10495-005-1896-x
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发表时间：
2005-05-01
期刊：
影响因子：
7.2
通讯作者：
Pandey, S
中科院分区：
文献类型：
--
作者：
McLachlan, A;Kekre, N;Pandey, S
对抗癌症的主要障碍是目前治疗的非特异性。寻找对正常细胞无细胞毒性并可有效靶向癌细胞的特定药物已导致一些研究人员研究天然化合物的潜在抗癌活性。一些天然化合物，如紫杉醇，已被证明具有一定的抗癌潜力。Pancratistatin（PST）是从海百合Pancratium littorale中分离得到的一种天然化合物，具有抗肿瘤活性。PST对癌细胞的特异性和PST的作用机制仍不清楚。这项研究详细研究了PST治疗对癌细胞和正常细胞的影响。我们的研究结果表明，PST选择性地诱导癌细胞凋亡，线粒体可能是PST在癌细胞中的作用部位。在癌细胞中特异性可用的生化靶标可能导致新的和更有效的抗癌剂的开发。
The major hurdle in the fight against cancer is the nonspecific nature of current treatments. The search for specific drugs that are non-cytotoxic to normal cells and can effectively target cancer cells has lead some researchers to investigate the potential anti-cancer activity of natural compounds. Some natural compounds, such as Taxol, have been shown to posses some anti-cancer potential. Pancratistatin (PST) is a natural compound that was isolated from the spider lily Pancratium littorale and shown to exhibit antineoplastic activity. The specificity of PST to cancer cells and the mechanism of PST's action remain unknown. This study provides a detailed look at the effect of PST treatment on cancerous and normal cells. Our results indicate that PST induced apoptosis selectively in cancer cells and that the mitochondria may be the site of action of PST in cancer cells. A biochemical target available specifically in cancer cells may lead to the development of new and more effective cancer fighting agents.