The prevalence of Gilles de la Tourette syndrome in children and adolescents with autism: a large scale study
The prevalence of Gilles de la Tourette syndrome in children and adolescents with autism: a large scale study
复制标题
DOI：
10.1017/s003329179900896x
复制
发表时间：
1999-09-01
影响因子：
6.9
通讯作者：
Robertson, MM
中科院分区：
文献类型：
--
作者：
Baron-Cohen, S;Scahill, VL;Robertson, MM
背景。早期一项针对自闭症儿童的小规模研究显示，8.1%的自闭症儿童同时患有多发性抽动秽语综合征（GTS）。本研究是对该结果是否可重复的大规模试验。来自9所儿童和青少年自闭症学校的447名学生接受了运动和声音联系的筛查。随后的家庭访谈证实了19名儿童明确的GTS合并症诊断，患病率为4.3%。另有10名儿童被诊断为可能的GTS（2.2%）。这些结果表明，自闭症中GTS的发生率偶然超过了预期，综合发生率（6.5%）与小规模研究中发现的发生率相似。讨论了方法上的考虑和患病率增加的其他解释。
Background. An earlier small-scale study of children with autism revealed that 8.1% of such patients were co-morbid for Gilles de la Tourette syndrome (GTS). The present study is a large scale test of whether this result replicates.Method. Four hundred and forty-seven pupils from nine schools for children and adolescents with autism were screened for the presence of motor and vocal ties.Results. Subsequent family interviews confirmed the co-morbid diagnosis of definite GTS in 19 children, giving a prevalence rate of 4.3%. A further 10 children were diagnosed with probable GTS (2.2%).Conclusions. These results indicate that the rate of GTS in autism exceeds that expected by chance, and the combined rate (6.5%)is similar to the rates found in the smaller-scale study. Methodological considerations and alternative explanations for an increased prevalence are discussed.