Schistosomiasis is associated with incident HIV transmission and death in Zambia
Schistosomiasis is associated with incident HIV transmission and death in Zambia
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DOI：
10.1371/journal.pntd.0006902
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发表时间：
2018-12-01
影响因子：
3.8
通讯作者：
Allen, Susan
中科院分区：
文献类型：
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作者：
Wall, Kristin M.;Kilembe, William;Allen, Susan
背景我们研究了血吸虫感染、HIV传播或获得性感染以及全因死亡之间的关系。方法我们采用嵌套式病例对照设计，对赞比亚卢萨卡一对异性恋HIV感染不和谐夫妇的基线血清进行了回顾性检测，并于1994-2012年进行了随访。用酶联免疫吸附试验检测血吸虫特异性抗体水平。对血吸虫抗原的基线抗体应答与HIV传播、获得性感染和按性别和HIV状况分层的全因死亡之间的相关性进行了评估。在HIV女性和HIV+男性的子集中，我们进行了免疫印迹试验，以评估血吸虫或曼氏血吸虫感染史与HIV发病率的关系。结果在2,145名个体中，59%的人基线血吸虫特异性抗体反应阳性。在HIV+的女性和男性中，基线的血吸虫特异性抗体与艾滋病毒传播给伴侣有关(调整后的风险比[AHR]=1.8，p
BackgroundWe examined relationships between schistosome infection, HIV transmission or acquisition, and all-cause death.MethodsWe retrospectively tested baseline sera from a heterosexual HIV-discordant couple cohort in Lusaka, Zambia with follow-up from 1994-2012 in a nested case-control design. Schistosome-specific antibody levels were measured by ELISA. Associations between baseline antibody response to schistosome antigens and incident HIV transmission, acquisition, and all-cause death stratified by gender and HIV status were assessed. In a subset of HIV women and HIV+ men, we performed immunoblots to evaluate associations between Schistosoma haematobium or Schistosoma mansoni infection history and HIV incidence.ResultsOf 2,145 individuals, 59% had positive baseline schistosome-specific antibody responses. In HIV+ women and men, baseline schistosome-specific antibodies were associated with HIV transmission to partners (adjusted hazard ratio [aHR] = 1.8, p