Reduced Specificity of Functional Connectivity in the Aging Brain During Task Performance
Reduced Specificity of Functional Connectivity in the Aging Brain During Task Performance
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DOI：
10.1002/hbm.22175
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发表时间：
2014-01-01
影响因子：
4.8
通讯作者：
Lorist, Monicque M.
中科院分区：
文献类型：
--
作者：
Geerligs, Linda;Maurits, Natasha M.;Lorist, Monicque M.
人们越来越认识到研究衰老大脑连通性的重要性。最近的研究表明，默认模式网络内的连通性随着年龄的增长而减少，并证明了这些变化与认知功能之间存在明确的关系。然而，对其他功能网络与年龄相关的变化的研究很少，并且主要集中在预先指定的功能网络上。使用功能磁共振成像，我们研究了一系列功能网络中视觉奇怪任务期间功能连接的与年龄相关的变化。研究发现，与年轻参与者相比，老年人属于同一功能网络的区域之间的连通性有所下降。这是在默认模式网络和躯体运动网络中发现的。此外，在所有已确定的网络中，老年人在这些网络内的区域与属于不同功能网络的区域之间的连接性有所增加。功能网络内的连通性下降与老年人认知功能较差有关。结果被解释为老年参与者的功能网络特异性下降。 Hum Brain Mapp 35:319-330, 2014。(c) 2012 Wiley periodicals, Inc.
The importance of studying connectivity in the aging brain is increasingly recognized. Recent studies have shown that connectivity within the default mode network is reduced with age and have demonstrated a clear relation of these changes with cognitive functioning. However, research on age-related changes in other functional networks is sparse and mainly focused on prespecified functional networks. Using functional magnetic resonance imaging, we investigated age-related changes in functional connectivity during a visual oddball task in a range of functional networks. It was found that compared with young participants, elderly showed a decrease in connectivity between areas belonging to the same functional network. This was found in the default mode network and the somatomotor network. Moreover, in all identified networks, elderly showed increased connectivity between areas within these networks and areas belonging to different functional networks. Decreased connectivity within functional networks was related to poorer cognitive functioning in elderly. The results were interpreted as a decrease in the specificity of functional networks in older participants. Hum Brain Mapp 35:319-330, 2014. (c) 2012 Wiley Periodicals, Inc.