A Tale of Two Immune Cells in Rheumatoid Arthritis: The Crosstalk Between Macrophages and T Cells in the Synovium.
A Tale of Two Immune Cells in Rheumatoid Arthritis: The Crosstalk Between Macrophages and T Cells in the Synovium.
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类风湿性关节炎中两种免疫细胞的故事：滑膜中巨噬细胞和T细胞之间的相互作用
DOI：
10.3389/fimmu.2021.655477
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发表时间：
2021
影响因子：
7.3
通讯作者：
Zhu C
中科院分区：
文献类型：
--
作者：
Tu J;Huang W;Zhang W;Mei J;Zhu C
类风湿性关节炎（RA）是一种慢性炎症性自身免疫性疾病。RA的关节炎症与免疫细胞浸润、滑膜增生、促炎细胞因子分泌过多等因素密切相关，导致软骨退化和骨质侵蚀。RA患者关节滑膜中含有多种免疫细胞类型，其中单核/巨噬细胞和T细胞是两种重要的细胞成分。单核/巨噬细胞可以募集并促进RA滑膜中T细胞分化为炎性表型。类似地，不同亚型的T细胞可以募集单核细胞/巨噬细胞并促进成骨细胞分化和炎性细胞因子的产生。本文就T细胞-单核细胞/巨噬细胞相互作用如何促进RA的发生发展进行综述，为RA的发病机制和靶向治疗提供新的视角。
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. Joint inflammation of RA is closely related to infiltration of immune cells, synovium hyperplasia, and superfluous secretion of proinflammatory cytokines, which lead to cartilage degradation and bone erosion. The joint synovium of RA patients contains a variety of immune cellular types, among which monocytes/macrophages and T cells are two essential cellular components. Monocytes/macrophages can recruit and promote the differentiation of T cells into inflammatory phenotypes in RA synovium. Similarly, different subtypes of T cells can recruit monocytes/macrophages and promote osteoblast differentiation and production of inflammatory cytokines. In this review, we will discuss how T cell-monocyte/macrophage interactions promote the development of RA, which will provide new perspectives on RA pathogenesis and the development of targeted therapy.
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影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
7.3
作者：
Fukui S;Iwamoto N;Takatani A;Igawa T;Shimizu T;Umeda M;Nishino A;Horai Y;Hirai Y;Koga T;Kawashiri SY;Tamai M;Ichinose K;Nakamura H;Origuchi T;Masuyama R;Kosai K;Yanagihara K;Kawakami A
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Kawakami A
影响因子：
7.3
作者：
Miyazaki, Yusuke;Nakayamada, Shingo;Tanaka, Yoshiya
通讯作者：
Tanaka, Yoshiya
影响因子：
15.9
作者：
Kim, CH;Rott, L;Butcher, EC
通讯作者：
Butcher, EC
影响因子：
6
作者：
Kim, Kyoung-Woon;Kim, Hae-Rim;Lee, Sang-Heon
通讯作者：
Lee, Sang-Heon