THE HOST-PARASITE RELATIONSHIPS IN PYRIDOXINE (VITAMIN-B6) DEFICIENT COTTON RATS INFECTED WITH LITOMOSOIDES-CARINII (NEMATODA, FILAROIDEA)
THE HOST-PARASITE RELATIONSHIPS IN PYRIDOXINE (VITAMIN-B6) DEFICIENT COTTON RATS INFECTED WITH LITOMOSOIDES-CARINII (NEMATODA, FILAROIDEA)
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DOI：
10.1017/s0031182000064660
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发表时间：
1995-07-01
期刊：
影响因子：
2.4
通讯作者：
STOREY, DM
中科院分区：
文献类型：
--
作者：
BEG, MA;FISTEIN, JL;STOREY, DM
研究结果表明，缺乏吡哆醇的棉花大鼠体内丝状线虫的建立和生长受到抑制。将幼龄棉大鼠分为三组：维生素b6缺乏棉大鼠（B6-AL）随意饲喂不含吡哆醇的饲料；配对饲养对照组（B6+PF）饲喂与缺陷组相同量的无吡哆醇饲粮，每日口服吡哆醇100 μ g；对照组（B6+AL）自由饲喂不含吡哆醇的饲粮，每日添加100 μ g吡哆醇。实验饲喂期开始8周后，每组半数小鼠皮下注射卡氏乳杆菌50 L(3)。缺乏b6的棉花大鼠比补充b6的对照组吃得少（P < 0.001），体重增加少（P < 0.001）。在整个实验过程中，每周通过血液涂片测量缺乏动物的微丝虫病水平，显著低于补充动物（P < 0.001）。在感染后20周，缺乏的大鼠开始潜伏卡氏乳杆菌，而其他饮食组的大鼠直到实验结束都有明显的微丝虫病。在感染后28周的尸检中，缺陷动物的胸膜和腹腔中发现的成虫比配对喂养或足够对照的成虫更小（P < 0.001）和更少（P < 0.05）。
This paper demonstrates that the establishment and growth of the filarial nematode parasite, Litomosoides carinii, is reduced in pyridoxine-deficient cotton rats. Young cotton rats were assigned to one of three dietary groups: vitamin B6-deficient cotton rats (B6-AL) were fed a pyridoxine-free diet ad libitum; pair-fed controls (B6+PF) were fed the same amount of pyridoxine-free diet as animals in the deficient group and given daily oral supplements of 100 mu g pyridoxine; and pyridoxine-sufficient controls (B6+AL) were fed the pyridoxine-free diet ad libitum and supplemented daily with 100 mu g pyridoxine. Half of each group was infected with 50 L(3) of L. carinii by subcutaneous injection 8 weeks after the start of the experimental feeding period. B6-deficient cotton rats ate less (P < 0.001) and gained less weight (P < 0.001) than B6-supplemented controls. The levels of microfilaraemia in deficient animals, measured weekly throughout the experiment by taking blood smears, was significantly lower than in supplemented animals (P < 0.001). The deficient rats became latent for L. carinii at 20 weeks post-infection, whereas there was patent microfilaraemia in rats in the other dietary groups until the end of the experiment. Smaller (P < 0.001) and fewer (P < 0.05) adult worms were recovered from the pleural and abdominal cavities of deficient animals than from either pair-fed or sufficient controls at autopsy 28 weeks post-infection.