Thiolate-bridged nickel-copper complexes: A binuclear model for the catalytic site of acetyl coenzyme A synthase?
Thiolate-bridged nickel-copper complexes: A binuclear model for the catalytic site of acetyl coenzyme A synthase?
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DOI：
10.1021/ja0346577
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发表时间：
2003-04-16
影响因子：
15
通讯作者：
Rheingold, AL
中科院分区：
文献类型：
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作者：
Krishnan, R;Voo, JK;Rheingold, AL
镍金属配体[EtN2S2]Ni(EtN2S2，N，N‘-二乙基-3，7-二氮杂-1，9-二硫酸酯)或K2[Ni(Phmi)](phmi，N，N‘-1，2-phenylenebis(2-sulfanyl-2-methylpropionamide)))与[Cu(CH3CN)4]BF4反应生成两个铜(I)离子通过镍金属配体桥联的多核配合物。或者，与铜(I)源[(PhTttBu)Cu](PhTttBu，苯基三((叔丁硫基)甲基)硼酸酯)反应，生成离散的双核NICU络合物，可以作为乙酰辅酶A合成酶活性中心的模型。双核物种通过硫代桥的断裂与CO发生可逆反应。
Reaction of the nickel metalloligands [EtN2S2]Ni (EtN2S2,N,N‘-diethyl-3,7-diazanonane-1,9-dithiolate) or K2[Ni(phmi)] (phmi,N,N‘-1,2-phenylenebis(2-sulfanyl-2-methylpropionamide)) with [Cu(CH3CN)4]BF4yields polynuclear complexes in which two copper(I) ions are bridged by the nickel metalloligands. Alternatively, reaction with the Cu(I) source, [(PhTttBu)Cu] (PhTttBu, phenyltris((tert-butylthio)methyl)borate), generates discrete binuclear NiCu complexes that may serve as models of the acetyl coenzyme A synthase active site. The binuclear species react reversibly with CO via rupture of the thiolate bridges.