Ovarian steroid modulation of prolactin surges in cervically stimulated ovariectomized rats.
Ovarian steroid modulation of prolactin surges in cervically stimulated ovariectomized rats.
复制标题
卵巢类固醇对宫颈刺激卵巢切除大鼠催乳素的调节激增。
作者：
M. Freeman;J. Sterman
在正常大鼠，宫颈刺激(CS)诱导的PRL分泌具有昼夜高峰(1900h)和夜间高峰(0500h)的特点，前者持续10天，后者持续11天。在去卵巢(OV)大鼠，CS引起的PRL波峰减弱，仅持续6天。本研究描述了SC硅橡胶植入雌二醇(E_2)或孕酮(P)对OV-CS大鼠催乳素(PRL)峰幅度和持续性的影响。在第0天(D-0)，1500h放置P和1900h放置CS可引起D-2上PRL的夜间峰，其幅度明显大于空白组。P组和空白组大鼠D-2上PRL的昼夜波峰相同。与空白植入大鼠相比，CS前一天0800小时给予E_2，D-0于1900小时给予E_2，D-2的PRL昼夜峰增强，夜间峰消失。在没有CS的情况下，OV大鼠对E2的反应表现为昼夜PRL激增。当激素植入延迟使用时。
PRL secretion induced by cervical stimulation (CS) in the intact rat is characterized by a daily diurnal surge (1900 h) which recurs for 10 days and a daily nocturnal surge (0500 h) which lasts for 11 days. In ovariectomized (OV) rats, CS induces attenuated PRL surges which last for only 6 days. This study describes the effect of SC Silastic implants of estradiol (E2) or progesterone (P) on the magnitude and persistence of PRL surges in OV-CS rats. Placement of P at 1500 h and CS at 1900 h day 0 (D-0) resulted in nocturnal surges of PRL on D-2 which were significantly greater than those of blank-implanted rats. Diurnal surges of PRL on D-2 were equivalent in P and blank-implanted rats. Placement of E2 at 0800 h on the day before CS at 1900 h on D-0 resulted in an enhanced diurnal surge and extinction of the nocturnal surge of PRL on D-2 compared to blank-implanted rats. In the absence of CS, OV rats presented diurnal but no nocturnal surges of PRL in response to E2. When steroid implantation was delayed u...