Quadriceps muscle thickness changes in patients with aneurysmal subarachnoid hemorrhage during the acute phase
Quadriceps muscle thickness changes in patients with aneurysmal subarachnoid hemorrhage during the acute phase
复制标题
动脉瘤性蛛网膜下腔出血急性期股四头肌厚度变化
DOI：
10.1080/10749357.2017.1413762
复制
发表时间：
2017
影响因子：
2.2
通讯作者：
Mase Kyoshi
中科院分区：
文献类型：
--
作者：
Nozoe Masafumi;Kanai Masashi;Kubo Hiroki;Kobayashi Miki;Yamamoto Miho;Shimada Shinichi;Mase Kyoshi
研究背景动脉瘤性蛛网膜下腔出血（aSAH）是一种危及生命的疾病，在相对年轻和健康的人群中经常导致严重残疾。这种残疾在许多aSAH幸存者中是身体上的，因此肌肉功能障碍可能是这些患者功能水平的重要因素。因此，测量肌肉厚度代表了用于确定急性aSAH患者的肌肉功能的合适方法，因为在急性期经常经历的意识障碍导致这些患者难以主动运动。目的我们研究了蛛网膜下腔出血患者股四头肌厚度的变化，以确定急性期的肌肉功能障碍是否与以下因素有关：（或预测）aSAH的结果。（平均年龄= 66 ± 11，男性/女性= 4/13）入组，结果股四头肌厚度较入院时明显降低，与入院时相比差异有统计学意义（P <0.05（平均值= 3.00 ± 0.72 cm）至第二次测量值（2.67 ± 0.74 cm，p= 0.001）。股四头肌厚度的相对差异与Hunt和Hess分级（r= − 0.72，p = 0.001）和90天时改良兰金量表评分（r= − 0.78，p = 0.0002.ConclusionsOur结果表明，急性蛛网膜下腔出血患者股四头肌厚度降低，尤其是Hunt和Hess分级较差或明显残疾的患者。
BackgroundAneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition that often leads to severe disability in relatively young and healthy people. This disability is physical in many aSAH survivors, so muscle dysfunction may be an important factor in the functional level of these patients. Thus, measuring muscle thickness represents a suitable method for determining muscle function in patients with acute aSAH, because the disordered consciousness often experienced during the acute phase causes active movement to be difficult for these patients.ObjectivesWe investigated changes in quadriceps muscle thickness in patients with aneurysmal subarachnoid hemorrhage to determine whether muscle dysfunction during the acute phase relates to (or predicts) the outcome of aSAH.MethodsSeventeen patients with aSAH (mean age = 66 ± 11, men/women = 4/13) were enrolled, and their quadriceps muscle thickness measured ultrasonographically upon admission and again 2 weeks later.ResultsQuadriceps muscle thickness significantly decreased from admission (mean = 3.00 ± 0.72 cm) to the second measurement (2.67 ± 0.74 cm,p= 0.001). The relative differences in quadriceps muscle thickness were correlated with the Hunt and Hess grade (r= −0.72,p= 0.001) and the modified Rankin Scale score at 90 days (r= −0.78,p= 0.0002).ConclusionsOur results indicate that quadriceps muscle thickness decreases in patients with acute aneurysmal subarachnoid hemorrhage, particularly in patients with poor Hunt and Hess grade or marked disability.