Small intestine CD4+ T cells are profoundly depleted during acute simian-human immunodeficiency virus infection, regardless of viral pathogenicity
Small intestine CD4+ T cells are profoundly depleted during acute simian-human immunodeficiency virus infection, regardless of viral pathogenicity
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DOI：
10.1128/jvi.02753-07
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发表时间：
2008-06-01
影响因子：
5.4
通讯作者：
Miura, Tomoyuki
中科院分区：
文献类型：
--
作者：
Fukazawa, Yoshinori;Miyake, Ariko;Miura, Tomoyuki
为了分析急性病毒诱导的损伤和随后的疾病表型之间的关系，我们比较了感染同基因高致病性（KS 661）和中等致病性（#64）猴-人免疫缺陷病毒（SHIV）的猴的病毒复制和CD 4（+）T细胞谱。直肠内输注SHIV-KS 661导致快速、全身和大量的病毒复制，而SHIV-#64复制更慢，滴度更低。而KS 661全身性地耗尽CD 4（+）T细胞，#64仅在小肠中引起显著的CD 4（+）T细胞耗尽。我们的结论是，SHIV，无论致病性如何，在急性感染过程中，可引起小肠损伤并导致受感染动物的CD 4（+）T细胞耗竭。
To analyze the relationship between acute virus-induced injury and the subsequent disease phenotype, we compared the virus replication and CD4(+) T-cell profiles for monkeys infected with isogenic highly pathogenic (KS661) and, moderately pathogenic (#64) simian-human immunodeficiency viruses (SHIVs). Intrarectal infusion of SHIV-KS661 resulted in rapid, systemic, and massive virus replication, while SHIV-#64 replicated more slowly and reached lower titers. Whereas KS661 systemically depleted CD4(+) T cells, #64 caused significant CD4(+) T-cell depletion only in the small intestine. We conclude that SHIV, regardless of pathogenicity, can cause injury to the small intestine and leads to CD4(+) T-cell depletion in infected animals during acute infection.