Molecular Biology and Evolution of Cancer: From Discovery to Action
Molecular Biology and Evolution of Cancer: From Discovery to Action
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DOI：
10.1093/molbev/msz242
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发表时间：
2020-02-01
影响因子：
10.7
通讯作者：
Townsend, Jeffrey P.
中科院分区：
文献类型：
--
作者：
Somarelli, Jason A.;Gardner, Heather;Townsend, Jeffrey P.
癌症的进展是一个进化的过程。在这个过程中，不断进化的癌细胞群体遇到了体内限制性的生态环境，如原发肿瘤、循环系统和不同的转移部位。预防或延缓癌症进化和进展的努力需要对潜在的分子进化过程有深刻的理解。在这里，我们讨论了一套来自进化和生态学理论的概念和工具，它们可以以新的和有意义的方式为癌症生物学提供信息。我们还强调了当前应用这些概念的挑战，并提出了结合这些概念可以识别癌症新的治疗模式和脆弱性的方法。
Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution-and progression-require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer.