Ultrahigh-speed non-invasive widefield angiography
Ultrahigh-speed non-invasive widefield angiography
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DOI：
10.1117/1.jbo.17.7.070505
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发表时间：
2012-07-01
影响因子：
3.5
通讯作者：
Leitgeb, Rainer A.
中科院分区：
文献类型：
--
作者：
Blatter, Cedric;Klein, Thomas;Leitgeb, Rainer A.
视网膜和脉络膜血管成像对老年性黄斑变性等眼部疾病具有重要的诊断价值。目前血管成像的金标准是荧光血管造影术。我们提出了一种潜在的基于功能傅立叶域光学相干断层成像(OCT)的血管成像的无创替代方案。为了与血管成像的视野和分辨率竞争，同时将运动伪影保持在最低限度，必须引入超高速成像。我们采用傅里叶域锁模扫描源技术，以高达1.68 MHz的A扫描速率提供高质量成像。我们呈现的视网膜血管图类似于在几秒钟内在一次记录中获得的48度，无需图像拼接。波长为1060 nm的OCT可以很好地穿透脉络膜，并能有效地区分视网膜和脉络膜血管。(C)2012年，光学仪器工程师学会。[DOI：10.1117/1.JBO.17.7.070505]
Retinal and choroidal vascular imaging is an important diagnostic benefit for ocular diseases such as age-related macular degeneration. The current gold standard for vessel visualization is fluorescence angiography. We present a potential non-invasive alternative to image blood vessels based on functional Fourier domain optical coherence tomography (OCT). For OCT to compete with the field of view and resolution of angiography while maintaining motion artifacts to a minimum, ultrahigh-speed imaging has to be introduced. We employ Fourier domain mode locking swept source technology that offers high quality imaging at an A-scan rate of up to 1.68 MHz. We present retinal angiogram over similar to 48 deg acquired in a few seconds in a single recording without the need of image stitching. OCT at 1060 nm allows for high penetration in the choroid and efficient separate characterization of the retinal and choroidal vascularization. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.7.070505]