Myc: Maestro of MicroRNAs.
Myc: Maestro of MicroRNAs.
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DOI：
10.1177/1947601910377491
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发表时间：
2010-06-01
期刊：
影响因子：
--
通讯作者：
Mendell JT
中科院分区：
文献类型：
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作者：
Bui TV;Mendell JT
Myc致癌转录因子的过度活性显著地重编程基因表达以促进细胞增殖和肿瘤发生。为了引起这些效应，Myc协调蛋白质编码基因的广泛网络的激活和抑制，并且如最近所认识到的，包括microRNA（miRNA）的非编码RNA。与其有效影响癌症表型的能力一致，Myc对miRNA的调节几乎影响Myc致癌程序的所有方面，包括增殖、存活、代谢、血管生成和转移。本文就Myc依赖的miRNAs转录和转录后调控机制及其对肿瘤发生的影响作一综述。由于miRNAs是Myc调控的转录网络中不可或缺的节点，因此调节其活性是一种很有前途的癌症治疗新方法。
Hyperactivity of the Myc oncogenic transcription factor dramatically reprograms gene expression to facilitate cellular proliferation and tumorigenesis. To elicit these effects, Myc coordinates the activation and repression of an extensive network of protein-coding genes and, as has recently been appreciated, noncoding RNAs including microRNAs (miRNAs). Consistent with their ability to potently influence cancer phenotypes, the regulation of miRNAs by Myc affects virtually all aspects of the Myc oncogenic program, including proliferation, survival, metabolism, angiogenesis, and metastasis. This review will summarize the current understanding of the mechanisms underlying Myc-dependent transcriptional and posttranscriptional control of miRNAs and the resultant effects on tumorigenesis. As miRNAs are integral nodes in the transcriptional network controlled by Myc, modulating their activity represents a promising new approach for cancer therapy.