EFFECTS OF DIETARY FATTY ACIDS ON FATTY ACID COMPOSITION OF BRAIN ETHANOLAMINE PHOSPHOGLYCERIDE - RECIPROCAL REPLACEMENT OF N-6 AND N-3 POLYUNSATURATED FATTY ACIDS
EFFECTS OF DIETARY FATTY ACIDS ON FATTY ACID COMPOSITION OF BRAIN ETHANOLAMINE PHOSPHOGLYCERIDE - RECIPROCAL REPLACEMENT OF N-6 AND N-3 POLYUNSATURATED FATTY ACIDS
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DOI：
10.1016/0005-2760(71)90233-5
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发表时间：
1971-01-01
期刊：
影响因子：
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通讯作者：
PAOLETTI, R
中科院分区：
文献类型：
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作者：
GALLI, C;TRZECIAK, HI;PAOLETTI, R
怀孕大鼠的饮食中添加了富含维生素6（红花油）或维生素3脂肪酸（鱼油）的油。饲喂断奶至90日龄的子代。研究了15、30、60和90日龄脑乙醇胺磷酸甘油酯脂肪酸组成。n-6和n-3家族脂肪酸在乙醇胺磷酸甘油酯分子中根据日粮中的量进行相互替换。亚油酸（n-6）代谢转化过程中的去饱和步骤主要受到给予大量n-3酸的动物的影响。在大脑中也是如此。膳食中的多不饱和长链脂肪酸（多不饱和长链脂肪酸家族）进入大脑，参与脑磷脂脂肪酸的代谢。两组大鼠脑内乙醇胺磷酸甘油脂肪酸的不饱和状态均保持不变。
Pregnant rats were given diets supplemented with oils rich either inn-6(safflower oil) or inn-3fatty acids (fish oil). The diets were given to the weaned progeny up to 90 days of age. The fatty acid composition of brain ethanolamine phosphoglyceride was studied at 15, 30, 60 and 90 days of age. Fatty acids of then-6and n-3 families undergo reciprocal replacement in the ethanolamine phosphoglyceride molecule according to the amounts in the diet. The desaturating steps in the metabolic conversion of linoleic (n-6) acid are mainly affected in animals given much n-3 acids. This is also true in brain. Dietary polyunsaturated long-chain fatty acids of then-3family enter the brain and became involved in the metabolism of fatty acids of brain phospholipids. The unsaturation of brain ethanolamine phosphoglyceride fatty acids was constant in both groups of rats.