TRANSFERRIN RECEPTORS IN HUMAN-TISSUES - THEIR DISTRIBUTION AND POSSIBLE CLINICAL RELEVANCE
TRANSFERRIN RECEPTORS IN HUMAN-TISSUES - THEIR DISTRIBUTION AND POSSIBLE CLINICAL RELEVANCE
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DOI：
10.1136/jcp.36.5.539
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发表时间：
1983-01-01
影响因子：
3.4
通讯作者：
MASON, DY
中科院分区：
文献类型：
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作者：
GATTER, KC;BROWN, G;MASON, DY
用4种单克隆抗体BK 19.9、B3/25、T56/14和T58/1研究了转铁蛋白受体（TR）在一系列正常和恶性组织中的分布。在正常组织中，TR仅见于少数部位，特别是基底表皮、内分泌胰腺、肝细胞、枯否细胞、睾丸和垂体。这种局限性分布模式可能与原发性血色病铁沉积的特征模式有关。与正常组织中的这种有限表达模式相反，该受体广泛分布于癌、肉瘤和霍奇金病病例的样本中。该受体的恶性相关表达可能通过与骨髓竞争血清铁而在晚期恶性肿瘤的贫血中发挥作用。
The distribution of transferrin receptors (TR) was studied in a range of normal and malignant tissues using 4 monoclonal antibodies, BK19.9, B3/25, T56/14 and T58/1. In normal tissues TR was found in a limited number of sites, notably basal epidermis, the endocrine pancreas, hepatocytes, Kupffer cells, testis and pituitary. This restricted pattern of distribution may be relevant to the characteristic pattern of iron deposition in primary hemachromatosis. In contrast to this limited pattern of expression in normal tissue, the receptor was widely distributed in carcinomas, sarcomas and in samples from cases of Hodgkin''s disease. This malignancy-associated expression of the receptor may play a role in the anemia of advanced malignancy by competing with the bone marrow for serum iron.