"Fleximers". Design and synthesis of a new class of novel shape-modified nucleosides
"Fleximers". Design and synthesis of a new class of novel shape-modified nucleosides
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DOI：
10.1021/jo0255476
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发表时间：
2002-05-17
影响因子：
3.6
通讯作者：
Quirk, S
中科院分区：
文献类型：
--
作者：
Seley, KL;Zhang, L;Quirk, S
介绍了一类新的构型修饰的核苷。这些新型的“柔韧性分子”的特点是腺苷、肌苷和鸟苷的嘌呤环系分裂成各自的咪唑和嘧啶组分(如图1-3)。这一结构修改为核苷带来了灵活性，同时仍保留了识别所必需的元素。因此，这些新型弹性体应该被用作生物探针，用于研究酶-辅酶结合部位以及核酸和蛋白质的相互作用。描述了它们的设计和合成。
A new class of shape-modified nucleosides is introduced. These novel "fleximers" feature the purine ring systems of adenosine, inosine, and guanosine split into their individual imidazole and pyrimidine components (as in 1-3). This structural modification serves to introduce flexibility into the nucleoside while still retaining the elements essential for recognition. As a consequence, these novel fleximers should find use as bioprobes for investigating enzyme-coenzyme binding sites as well as nucleic acid and protein interactions. Their design and synthesis are described.