Molecular imaging reveals unique degenerative changes in experimental glaucoma
Molecular imaging reveals unique degenerative changes in experimental glaucoma
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DOI：
10.1097/wnr.0b013e32831d7f82
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发表时间：
2009-01-28
期刊：
影响因子：
1.7
通讯作者：
Watanabe, Yasuyoshi
中科院分区：
文献类型：
--
作者：
Imamura, Kazuyuki;Onoe, Hirotaka;Watanabe, Yasuyoshi
在患有单侧高血压性青光眼的猴子中，使用正电子发射断层扫描研究了实验诱导的中枢视觉通路的变化。在2-[F-18]氟-2-脱氧-葡萄糖研究中，对患眼进行单眼视觉刺激可显著降低枕叶视皮质区的神经反应。反应减少仅限于患眼同侧的视觉皮层，表明实验性单侧青光眼中同侧视觉皮层的独特脆弱性。此外，在[C-11] PK 11195正电子发射断层扫描和免疫组织化学研究中，在双侧外侧膝状体核中发现了活化小胶质细胞的选择性积聚，这是神经变性的标志。目前的研究结果通过为青光眼的早期阶段提供更清晰的替代终点，确立了非侵入性分子成像在青光眼早期诊断中的有用性。NeuroReport 20：139-144（C）2009 Wolters Kluwer Health垂直酒吧Lippincott威廉姆斯&威尔金斯。
Experimentally induced changes in the central visual pathway were studied by using positron emission tomography in monkeys with unilateral hypertension glaucoma. In 2-[F-18]fluoro-2-deoxy-glucose studies, monocular visual stimulation of the affected eye yielded significantly reduced neural responses in the occipital visuocortical areas. The response reduction was limited to the visual cortex ipsilateral to the affected eye, indicating the unique vulnerability of ipsilateral visual cortex in experimental unilateral glaucoma. In addition, in [C-11]PK11195 positron emission tomography and immunohistochemical studies, selective accumulation of activated microglia, a sign of neural degeneration, was found bilaterally in lateral geniculate nuclei. The present findings establish the usefulness of noninvasive molecular imaging for early diagnosis of glaucoma by providing a sharper surrogate end point for an early phase of glaucoma. NeuroReport 20:139-144 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.