S-100 protein in "follicular dendritic" cells or rat lymphoid organs. An immunochemical and immunocytochemical study.
S-100 protein in "follicular dendritic" cells or rat lymphoid organs. An immunochemical and immunocytochemical study.
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“滤泡树突”细胞或大鼠淋巴器官中的 S-100 蛋白。
DOI：
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发表时间：
1983
影响因子：
3.6
通讯作者：
F. Michetti
中科院分区：
文献类型：
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作者：
D. Cocchia;G. Tiberio;R. Santarelli;F. Michetti
采用微补体定量固定法和免疫细胞化学PAP法在超微结构水平上研究了S-100蛋白在成年大鼠淋巴器官中的存在及其细胞和亚细胞分布。该蛋白似乎局限于淋巴结和脾脏的“滤泡树突状”细胞，已知其仅与次级滤泡中的B淋巴细胞相关。目前的数据显示S-100在神经系统外还有一个额外的位置。这种蛋白质也可能是一种有用的工具，可以提供关于“滤泡树突状”细胞的起源和功能的信息，这些信息仍然知之甚少。
The presence as well as the cellular and subcellular distribution of S-100 protein were investigated in lymphoid organs of the adult rat by quantitative microcomplement fixation assay and by the immunocytochemical PAP method at the ultrastructural level. The protein appeared to be confined to the "follicular dendritic" cells both in the lymph node and the spleen, which are known to be exclusively associated with B lymphocytes in secondary follicles. The present data show an additional location for S-100 outside the nervous system. The protein may also be a useful tool to provide information on the origin and function of "follicular dendritic" cells, which are still poorly understood.