TYLOSIN TARTRATE AND TIAMUTILIN EFFECTS ON EXPERIMENTAL PIGLET PNEUMONIA INDUCED WITH PNEUMONIC PIG LUNG HOMOGENATE CONTAINING MYCOPLASMAS, BACTERIA AND VIRUSES
TYLOSIN TARTRATE AND TIAMUTILIN EFFECTS ON EXPERIMENTAL PIGLET PNEUMONIA INDUCED WITH PNEUMONIC PIG LUNG HOMOGENATE CONTAINING MYCOPLASMAS, BACTERIA AND VIRUSES
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DOI：
10.1016/s0034-5288(18)32364-6
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发表时间：
1982-01-01
影响因子：
2.4
通讯作者：
FISH, JP
中科院分区：
文献类型：
--
作者：
HANNAN, PCT;BHOGAL, BS;FISH, JP
用天然获得性地方性肺炎猪肺匀浆实验研究了酒石酸泰乐素和替阿穆林对新生仔猪肺炎诱导的作用。匀浆中含有支原体，包括猪肺炎支原体（猪肺炎支原体）和猪支原体以及某些细菌和病毒。实验性肺炎与支原体肺炎大体相似，但部分动物合并吸入性肺炎。酒石酸泰乐新（50 mg/kg）和替阿穆林（10 mg/kg）每日口服两次，从鼻内感染后14天开始，连续10天，显著降低了宏观肺病变的发生率和严重程度。猪肺炎支原体可从未给药仔猪的肺中分离出来，但不能从给药仔猪的肺中分离出来。经药物治疗后，猪肺组织中嗜鼻支原体、颗粒无形体、副猪嗜血杆菌、多杀性巴氏杆菌和溶血假单胞菌的数量均显著减少。细菌在实验感染中的作用似乎是继发性入侵者。
The effects of tylosin tartrate and tiamutilin were examined in pneumonias induced experimentally in neonatal piglets with a homogenate of pneumonic pig lung, obtained from pigs with naturally acquired enzootic pneumonia. The homogenate contained mycoplasmas, including Mycoplasma hyopneumoniae (M. suipneumoniae) and M. hyorhinis and certain bacteria and viruses. The experimental pneumonias generally resembled mycoplasmal pneumonia histologically but were complicated by aspiration pneumonia in some animals. Tylosin tartrate (50 mg/kg) and tiamutilin (10 mg/kg) administered orally twice daily for 10 days, beginning 14 days after intranasal infection, significantly reduced the incidence and severity of macroscopical pneumonic lung lesions. M. hyopneumoniae could be isolated from the lungs of the unmedicated piglets, but not from drug-treated piglets. The numbers of M. hyorhinis, Acholeplasma granularum, Haemophilus parasuis, Pasteurella multocida and P. haemolytica in the lung tissue of the infected piglets were significantly reduced by drug therapy. The role of bacteria in the experimental infection appeared to be that of secondary invaders.