Biology of the Sinus Node and its Disease
Biology of the Sinus Node and its Disease
复制标题
DOI：
10.15420/aer.2015.4.1.28
复制
发表时间：
2015-03-01
影响因子：
3
通讯作者：
Morris, Gwilym M.
中科院分区：
文献类型：
--
作者：
Choudhury, Moinuddin;Boyett, Mark R.;Morris, Gwilym M.
窦房结（SAN）是心脏的正常起搏点，窦房结功能障碍（SND）是常见的，但直到最近的病理生理学不完全了解。它通常归因于特发性年龄相关性纤维化和细胞萎缩或缺血。现在很明显，SAN的电生理学变化（称为电重构）是一个重要的过程，已在与心力衰竭、衰老、糖尿病、房颤和耐力运动相关的SND中得到证实。此外，家族性SND已被确定，突变已在SAN的关键起搏基因的特点。本文综述了目前有关SAN功能和SND病理生理学的证据。
The sinoatrial node (SAN) is the normal pacemaker of the heart and SAN dysfunction (SND) is common, but until recently the pathophysiology was incompletely understood. It was usually attributed to idiopathic age-related fibrosis and cell atrophy or ischaemia. It is now evident that changes in the electrophysiology of the SAN, known as electrical remodelling, is an important process that has been demonstrated in SND associated with heart failure, ageing, diabetes, atrial fibrillation and endurance exercise. Furthermore, familial SND has been identified and mutations have been characterised in key pacemaker genes of the SAN. This review summarises the current evidence regarding SAN function and the pathophysiology of SND.