Using point clouds to investigate the relationship between trabecular bone phenotype and behavior: An example utilizing the human calcaneus
Using point clouds to investigate the relationship between trabecular bone phenotype and behavior: An example utilizing the human calcaneus
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DOI：
10.1002/ajhb.23468
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发表时间：
2020-08-13
影响因子：
2.9
通讯作者：
Ryan, Timothy M.
中科院分区：
文献类型：
--
作者：
DeMars, Lily J. D.;Stephens, Nicholas B.;Ryan, Timothy M.
目的探讨骨小梁体积分数和各向异性程度的三维分析方法。方法采用自动网格配准、点云对应配准和P值校正单变量统计检验相结合的方法，逐点比较两组不同生存策略人群跟骨的骨体积分数和各向异性程度。结果我们发现，黑土(狩猎-采集者)和Norris Farm(混合策略农场主)之间的高、低骨体积分数和各向异性分布程度非常相似，但在大小上有所不同。狩猎-采集者表现出较高的骨体积分数和较少的各向异性骨小梁组织。此外，跟骨中的骨体积分数和各向异性程度与行走和跑步过程中所经历的相对力的生物力学预期很好地一致。结论比较骨体积分数和骨各向异性程度等松质骨变量在三维方向上的局部差异是一种强有力的分析工具。这种方法可以确定组之间的相似性和差异性在整个感兴趣的骨骼元素中的位置。多变量的可视化还为研究人员提供了一种方法，以了解松质骨变量如何在形态学中相互作用，并允许更细微地了解它们彼此之间以及更广泛的力学环境之间的关系。
Objectives The objective of this study is to demonstrate a new method for analyzing trabecular bone volume fraction and degree of anisotropy in three dimensions. Methods We use a combination of automatic mesh registration, point-cloud correspondence registration, andP-value corrected univariate statistical tests to compare bone volume fraction and degree of anisotropy on a point by point basis across the entire calcaneus of two human groups with different subsistence strategies. Results We found that the patterns of high and low bone volume fraction and degree of anisotropy distribution between the Black Earth (hunter-gatherers) and Norris Farms (mixed-strategy agriculturalists) are very similar, but differ in magnitude. The hunter-gatherers exhibit higher levels of bone volume fraction and less anisotropic trabecular bone organization. Additionally, patterns of bone volume fraction and degree of anisotropy in the calcaneus correspond well with biomechanical expectations of relative forces experienced during walking and running. Conclusions We conclude that comparing site-specific, localized differences in trabecular bone variables such as bone volume fraction and degree of anisotropy in three-dimensions is a powerful analytical tool. This method makes it possible to determine where similarities and differences between groups are located within the whole skeletal element of interest. The visualization of multiple variables also provides a way for researchers to see how the trabecular bone variables interact within the morphology, and allows for a more nuanced understanding of how they relate to one another and the broader mechanical environment.