STEROID SEX-HORMONES REGULATE THE RELEASE OF TUMOR-NECROSIS-FACTOR BY MACROPHAGES
STEROID SEX-HORMONES REGULATE THE RELEASE OF TUMOR-NECROSIS-FACTOR BY MACROPHAGES
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DOI：
10.1016/0008-8749(95)80007-6
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发表时间：
1995-01-01
影响因子：
4.3
通讯作者：
WALTER, RJ
中科院分区：
文献类型：
--
作者：
CHAO, TC;VANALTEN, PJ;WALTER, RJ
一般来说，女性已被发现有一个增强的免疫反应和随之而来的自身免疫性疾病的发病率高于男性。用雄性大鼠腹腔巨噬细胞（M phi）研究雌性激素对肿瘤坏死因子（TNF）释放的影响。（分别为35.1 +/- 7.3和23.2 +/- 2.5单位/ml）显著（P < 0.05; n = 9）大于未处理的M phi的释放。预后（P）也显著（P < 0.05; n = 8）刺激最大TNF释放（24.4 +/- 2.8单位/ml TNF），10（-2）ng/ml，另一方面，暴露于浓度大于10（-1）或小于10（-4）ng/ml的E（2）或P时，M phi释放的TNF量显著高于对照组（P < 0.05）。与未处理的对照相比降低（P < 0.05）。相比之下，睾酮在任何浓度下都不会显著影响TNF的释放。在E（2）和P浓度的生理范围内，来自M phi的TNF释放受到激素浓度的相对小的变化的精细调节和显著影响，（C）1995 Academic Press，Inc.
Generally, females have been found to have a heightened immune response and a concomitantly higher incidence of autoimmune diseases compared to males. We have used male rat peritoneal macrophages (M phi) to study the effect of female sex hormones on tumor necrosis factor (TNF) release, The amount of TNF released by macrophages (M phi) exposed to 10(-2) and 10(-3) ng/ml of 17 beta-estradiol (E(2)) (35.1 +/- 7.3 and 23.2 +/- 2.5 units/ml, respectively) was significantly (P < 0.05; n = 9) greater than that released by untreated M phi. Progesterone (P) also significantly (P < 0.05; n = 8) stimulated a maximal TNF release (24.4 +/- 2.8 units/ml TNF) at 10(-2) ng/ml, On the other hand, the amount of TNF released by M phi exposed to E(2) or P at concentrations greater than 10(-1) or less than 10(-4) ng/ml was significantly (P < 0.05) reduced compared to untreated controls. In contrast, testosterone did not significantly affect TNF release at any concentration. Within the physiological range of E(2) and P concentrations, TNF release from M phi is finely regulated and dramatically affected by relatively small changes in hormone concentrations, (C) 1995 Academic Press, Inc.