Relationship between Duration of Infant Exposure to a Moderate-to-Large Patent Ductus Arteriosus Shunt and the Risk of Developing Bronchopulmonary Dysplasia or Death Before 36 Weeks.
Relationship between Duration of Infant Exposure to a Moderate-to-Large Patent Ductus Arteriosus Shunt and the Risk of Developing Bronchopulmonary Dysplasia or Death Before 36 Weeks.
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DOI：
10.1055/s-0039-1697672
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发表时间：
2020-01
影响因子：
2
通讯作者：
Johng, Sandy
中科院分区：
文献类型：
--
作者：
Clyman, Ronald I.;Hills, Nancy K.;Liebowitz, Melissa;Johng, Sandy
研究婴儿暴露于中大型动脉导管未闭（PDA）分流术的持续时间与发生支气管肺发育不良（BPD）或36周前死亡（BPD/死亡）的风险之间的关系。存活≥7天的妊娠<28周的婴儿（n=423）在第7天和计划的时间间隔进行超声心动图检查。在多变量回归模型中，BPD/死亡似乎没有增加，直到婴儿暴露于中度至重度PDA至少7-13天：OR（95%CI）（参考=闭合或小PDA）：中度至大型PDA暴露<7天：0.38（0.10-1.46）; 7-13天= 2.12（1.04-4.32）; ≥14天=3.86（2.15-6.96）。一旦达到7-13天的阈值，（≥14天）未显著增加BPD/死亡的发生率：（参考暴露=7-13天）：暴露14-27天=1.34（0.52-3.45）; 28-48天=2.34（0.88-6.19）; ≥49天=1.80（0.59-5.47））。BPD单独治疗的结果也存在类似的关系。妊娠< 28周的婴儿在BPD/死亡的发生率明显增加之前，至少需要暴露于中度至重度PDA 7-13天。一旦达到该阈值，额外暴露于中大型PDA不会显著增加BPD/死亡的发生率。
To examine the relationship between duration of infant exposure to a moderate-to-large patent ductus arteriosus (PDA) shunt and the risk of developing bronchopulmonary dysplasia (BPD) or death before 36 weeks (BPD/Death). Infants <28 weeks’ gestation who survived ≥7 days (n=423) had echocardiograms performed on day 7 and at planned intervals. In multivariable regression models, BPD/Death did not appear to be increased until infants had been exposed to a moderate-to-large PDA for at least 7-13 days: OR (95%CI) (referent=closed or small PDA): moderate-to-large PDA exposure for <7 days: 0.38 (0.10-1.46); for 7-13 days= 2.12 (1.04-4.32); for ≥14 days=3.86 (2.15-6.96). Once the threshold of 7-13 days had been reached, additional exposure (≥14 days) did not significantly add to the increased incidence of BPD/Death: (referent exposure=7-13 days): exposure for 14-27 days=1.34 (0.52-3.45); for 28-48 days=2.34 (0.88-6.19); for ≥49 days=1.80 (0.59-5.47)). A similar relationship was found for the outcome of BPD-alone. Infants < 28 weeks’ gestation required at least 7-13 days of exposure to a moderate-to-large PDA before a significant increase in the incidence of BPD/Death was apparent. Once this threshold was reached additional exposure to a moderate-to-large PDA did not significantly add to the increased incidence of BPD/Death.
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PDA-验证试验：一项探索性随机对照试验，是对1周大的中度至大型专利导管的治疗。
DOI：
10.1016/j.jpeds.2018.09.012
发表时间：
2019-03
期刊：
The Journal of pediatrics
影响因子：
--
作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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作者：
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