IMPROVED ARTERIAL DISTENSIBILITY IN NORMOTENSIVE SUBJECTS ON A LOW SALT DIET
IMPROVED ARTERIAL DISTENSIBILITY IN NORMOTENSIVE SUBJECTS ON A LOW SALT DIET
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DOI：
10.1161/01.atv.6.2.166
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发表时间：
1986-03-01
期刊：
影响因子：
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通讯作者：
OROURKE, MF
中科院分区：
文献类型：
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作者：
AVOLIO, AP;CLYDE, KM;OROURKE, MF
动脉脉搏波速度（PWV），动脉扩张性的非侵入性指标，在57名血压正常的受试者谁遵循自愿低盐饮食8个月至5年（平均24.8个月）的时间范围内进行了测量。遵循常规饮食的受试者在年龄和平均动脉压方面与低盐（LS）样本相匹配，并用作对照（C）。对于两个样本，受试者被分为三个年龄组：第1组（2至19岁，n = 16），第2组（29至44岁，n = 26）和第3组（45至66岁，n = 15）。对照样本的主动脉PWV随年龄显著增加，而LS样本则无此现象。第1组的主动脉PWV无显著差异，但在第2组和第3组中，LS受试者与C受试者相比分别降低了21.8%和22.7%。主动脉PWV（cm/sec）为：组1：C = 581（SE 44），LS = 614（SE 31）;组2：C = 942（SE 46）; LS = 737（SE 27）（p < 0.001）;组3：C = 958（SE 77），LS = 741（SE 25）（p < 0.05）。老年组的手臂和腿部PWV也显着较低。这些结果表明，遵循低盐饮食（平均摄入量，44 mmol Na/24小时）的血压正常的成年受试者动脉僵硬度降低，并且该效果与血压无关。这是初步证据，表明减少盐摄入量对改善中央主动脉和大外周动脉的扩张性具有有益作用，这与其降压作用无关。
Arterial pulse wave velocity (PWV), a noninvasive index of arterial distensibility, was measured in 57 normotensive subjects who followed a voluntary low salt diet for a period ranging from 8 months to 5 years (mean, 24.8 months). Subjects who followed a regular diet were matched for age and mean arterial pressure with the low salt (LS) sample and were used as controls (C). For both samples, subjects were divided into three age groups: Group 1 (aged 2 to 19 years, n = 16), Group 2 (29 to 44 years, n = 26), and Group 3 (45 to 66 years, n = 15). There was a marked increase in aortic PWV with age in the control sample but not in the LS sample. There was no significant difference in aortic PWV for Group 1, but in Groups 2 and 3, the LS subjects showed a decrease of 21.8% and 22.7%, respectively, compared to C subjects. Aortic PWV (cm/sec) was: Group 1: C = 581 (SE 44), LS = 614 (SE 31); Group 2: C = 942 (SE 46); LS = 737 (SE 27) (p < 0.001); Group 3: C = 958 (SE 77), LS = 741 (SE 25) (p < 0.05). Arm and leg PWV were also significantly lower in the older age groups. These findings suggest that normotensive adult subjects who follow a low salt diet (mean intake, 44 mmol Na/24 hours) have reduced arterial stiffness and that the effect is independent of blood pressure. This is prima facie evidence that reduced salt intake has a beneficial effect in improving distensibility of the central aorta and large peripheral arteries, which is independent of its antihypertensive action.