Haemorrhagic cystitis following the administration of voriconazole in the treatment of central nervous system aspergillosis: a case report
Haemorrhagic cystitis following the administration of voriconazole in the treatment of central nervous system aspergillosis: a case report
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伏立康唑治疗中枢神经系统曲霉菌病后出血性膀胱炎：病例报告
DOI：
10.1177/0300060520974924
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发表时间：
2020-12
影响因子：
1.6
通讯作者：
Zhaohao Zeng
中科院分区：
文献类型：
--
作者：
Yu Zhang;Lianfang Xue;Wei Bi;Haimei Cen;Kunyu Huang;Hong Luo;Hui Liu;Lu Wang;Xiaoting Li;Zhaohao Zeng
Central nervous system aspergillosis (CNS-A) is a rare and fatal fungal infection. Voriconazole is the recommended treatment for CNS-A. The therapeutic effect of voriconazole is good, but its use is limited due to adverse reactions. This case report describes a 37-year-old male patient that had previously been diagnosed with acute lymphoblastic leukaemia. He had received immunosuppressive agents for 1 year following a haematopoietic bone marrow transplant. He presented with a 1-month history of left limb weakness as well as recurrent fever. Brain magnetic resonance imaging showed that he had multiple cerebral infarctions. Subsequently, he was diagnosed with CNS-A by metagenomic next-generation sequencing. Voriconazole was added to his treatment regimen, but it resulted in severe haemorrhagic cystitis and possibly bladder rupture. The dose of voriconazole was adjusted and reparative bladder surgery was undertaken immediately. Eventually, the patient was successfully treated with voriconazole and there was no recurrence of symptoms after 1 year of follow-up. Haemorrhagic cystitis is a rare adverse drug reaction associated with voriconazole use. Based on the experience with this current case, physicians should be aware of urinary tract complications with voriconazole including haemorrhagic cystitis.
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DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
H. S. Martins;Thiago Rodrigo da Silva;Augusto Scalabrini-Neto;I. Velasco
通讯作者：
H. S. Martins;Thiago Rodrigo da Silva;Augusto Scalabrini-Neto;I. Velasco
DOI：
--
发表时间：
1990
期刊：
--
影响因子：
--
作者：
M. F. Parry
通讯作者：
M. F. Parry
影响因子：
20.3
作者：
Schwartz, S;Ruhnke, M;Thiel, E
通讯作者：
Thiel, E
DOI：
--
发表时间：
1995-03
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Y. Miaux;P. Ribaud;M. Williams;A. Guermazi;E. Gluckman;C. Brocheriou;M. Laval-jeantet
通讯作者：
Y. Miaux;P. Ribaud;M. Williams;A. Guermazi;E. Gluckman;C. Brocheriou;M. Laval-jeantet
影响因子：
2
作者：
Muraoka, Shinsuke;Araki, Yoshio;Wakabayashi, Toshihiko
通讯作者：
Wakabayashi, Toshihiko