Impairment in task-specific modulation of muscle coordination correlates with the severity of hand impairment following stroke.
Impairment in task-specific modulation of muscle coordination correlates with the severity of hand impairment following stroke.
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DOI：
10.1371/journal.pone.0068745
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Kamper DG
中科院分区：
文献类型：
--
作者：
Lee SW;Triandafilou K;Lock BA;Kamper DG
在中风幸存者中经常观察到明显的手功能障碍。我们以前的研究表明，不能根据任务要求调节肌肉协调模式可能是实质性的中风后，但这些限制还没有被直接检查。在这项研究中，我们的目的是表征中风后障碍的能力，调节肌肉协调模式的任务及其与手损伤的相关性。14名中风幸存者参加了实验，根据他们的临床功能评分分为重度手损伤组（8名受试者）和中度手损伤组（6名受试者）。另外四名神经系统完整的受试者参加了实验，作为比较点。当受试者执行六个等长任务时，使用表面肌电图记录了九个手部和腕部肌肉的激活模式。不同任务之间肌肉激活的协变模式，即，从肌肉激活数据中提取肌肉模块。我们的研究结果表明，多肌肉激活模式的任务间分离的减少程度指示受试者的临床功能评分（严重受损受试者的平均值=26.2，中度受损受试者的平均值= 38.1）。 中度受损受试者的值更接近受损受试者的值（平均值= 46.1）。 从受试者的肌肉激活模式中提取的肌肉模块的数量（代表运动复杂性的程度）与临床功能评分相关（R = 0.68）。 更大的损伤也与肌肉模块模式本身的变化相关，具有更大的肌肉共激活。中风后多肌肉协调的自由度明显降低，并且通过所述指标评估的降低程度与临床损伤水平密切相关。
Significant functional impairment of the hand is commonly observed in stroke survivors. Our previous studies suggested that the inability to modulate muscle coordination patterns according to task requirements may be substantial after stroke, but these limitations have not been examined directly. In this study, we aimed to characterize post-stroke impairment in the ability to modulate muscle coordination patterns across tasks and its correlation with hand impairment. Fourteen stroke survivors, divided into a group with severe hand impairment (8 subjects) and a group with moderate hand impairment (6 subjects) according to their clinical functionality score, participated in the experiment. Another four neurologically intact subjects participated in the experiment to serve as a point of comparison. Activation patterns of nine hand and wrist muscles were recorded using surface electromyography while the subjects performed six isometric tasks. Patterns of covariation in muscle activations across tasks, i.e., muscle modules, were extracted from the muscle activation data. Our results showed that the degree of reduction in the inter-task separation of the multi-muscle activation patterns was indicative of the clinical functionality score of the subjects (mean value = 26.2 for severely impaired subjects, 38.1 for moderately impaired subjects). The values for moderately impaired subjects were much closer to those of the impaired subjects (mean value = 46.1). The number of muscle modules extracted from the muscle activation patterns of a subject across six tasks, which represents the degree of motor complexity, was found to be correlated with the clinical functionality score (R = 0.68). Greater impairment was also associated with a change in the muscle module patterns themselves, with greater muscle coactivation. A substantial reduction in the degrees-of-freedom of the multi-muscle coordination post-stroke was apparent, and the extent of the reduction, assessed by the stated metrics, was strongly associated with the level of clinical impairment.
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影响因子：
2.8
作者：
AN, KN;CHAO, EY;LINSCHEID, RL
通讯作者：
LINSCHEID, RL
影响因子：
2.5
作者：
GALGANSKI, ME;FUGLEVAND, AJ;ENOKA, RM
通讯作者：
ENOKA, RM
DOI：
10.1016/s0003-9993(99)90225-3
发表时间：
1999-07-01
影响因子：
4.3
作者：
Beer, RF;Given, JD;Dewald, JPA
通讯作者：
Dewald, JPA
影响因子：
2
作者：
Ellis, Michael D.;Acosta, Ana Maria;Dewald, Julius P. A.
通讯作者：
Dewald, Julius P. A.
DOI：
10.1111/j.1469-8749.1984.tb04445.x
发表时间：
1984-01-01
影响因子：
3.8
作者：
ELLIOTT, JM;CONNOLLY, KJ
通讯作者：
CONNOLLY, KJ