Calmodulin activation of adenylate cyclase in pancreatic islets.
Calmodulin activation of adenylate cyclase in pancreatic islets.
复制标题
钙调蛋白激活胰岛中的腺苷酸环化酶。
作者：
I. Valverde;A. Vandermeers;R. Anjaneyulu;W. Malaisse
胰岛含有钙调蛋白。该蛋白质与源自胰岛的颗粒部分结合，并刺激该亚细胞部分中的腺苷酸环化酶活性，这两种现象均被离子钙激活。内源性钙调蛋白对腺苷酸环化酶的钙依赖性刺激可能有助于胰岛素释放剂在胰岛细胞中引起的 3',5'-单磷酸腺苷的积累。
Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.