Mapping of neurokinin-like immunoreactivity in the human brainstem -: art. no. 3
Mapping of neurokinin-like immunoreactivity in the human brainstem -: art. no. 3
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DOI：
10.1186/1471-2202-4-3
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发表时间：
2003-02-04
期刊：
影响因子：
2.4
通讯作者：
Gonzalez-, S
中科院分区：
文献类型：
--
作者：
Coveñas, R;Martin, F;Gonzalez-, S
背景资料：利用间接免疫过氧化物酶技术，我们研究了无神经或精神疾病史的成年人脑干中含有神经激肽的免疫反应纤维和细胞体的分布。成簇的免疫反应细胞体和高密度的神经激肽免疫反应纤维位于导水管周围灰质、迷走神经背侧运动核和延髓的网状结构中，脑桥和中脑此外，免疫反应阳性细胞体被发现在下丘，中缝隐，前置核的舌下，并在中线的前延髓。在一般情况下，含有神经激肽的免疫反应纤维观察到整个脑干。除上述核团外，三叉神经脊束核、外侧网状核、孤束核、上级丘、黑质、疑核、薄束核、楔束核、舌下神经运动核、前庭内侧核和上级核、结论：神经激肽在人脑干内广泛分布，可能作为神经递质和/或神经调质参与多种生理机制。
Background: Using an indirect immunoperoxidase technique, we have studied the distribution of immunoreactive fibers and cell bodies containing neurokinin in the adult human brainstem with no prior history of neurological or psychiatric disease.Results: Clusters of immunoreactive cell bodies and high densities of neurokinin-immunoreactive fibers were located in the periaqueductal gray, the dorsal motor nucleus of the vagus and in the reticular formation of the medulla, pons and mesencephalon. Moreover, immunoreactive cell bodies were found in the inferior colliculus, the raphe obscurus, the nucleus prepositus hypoglossi, and in the midline of the anterior medulla oblongata. In general, immunoreactive fibers containing neurokinin were observed throughout the whole brainstem. In addition to the nuclei mentioned above, the highest densities of such immunoreactive fibers were located in the spinal trigeminal nucleus, the lateral reticular nucleus, the nucleus of the solitary tract, the superior colliculus, the substantia nigra, the nucleus ambiguus, the gracile nucleus, the cuneate nucleus, the motor hypoglossal nucleus, the medial and superior vestibular nuclei, the nucleus prepositus hypoglossi and the interpeduncular nucleus.Conclusion: The widespread distribution of immunoreactive structures containing neurokinin in the human brainstem indicates that neurokinin might be involved in several physiological mechanisms, acting as a neurotransmitter and/or neuromodulator.