Axonal signals in central nervous system myelination, demyelination and remyelination
Axonal signals in central nervous system myelination, demyelination and remyelination
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DOI：
10.1016/j.jns.2005.03.029
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发表时间：
2005-06-15
影响因子：
4.4
通讯作者：
Lubetzki, C
中科院分区：
文献类型：
--
作者：
Coman, L;Barbin, G;Lubetzki, C
轴突信号是中枢神经系统髓鞘形成的关键因素。在发育过程中，髓鞘形成的开始取决于正轴突信号和负轴突信号之间的平衡。负面信号包括抑制性粘附分子，需要从细胞表面去除这些分子才能使髓鞘形成过程继续进行。启动髓鞘形成所需的正信号包括与特定粘附分子的相互作用和电活动诱导的髓鞘形成因子的释放。在多发性硬化症中，脱髓鞘引起轴突表面成分的重大改变。这些因素的破坏可能会导致髓磷脂修复过程的失败。 (c) 2005 Elsevier B.V. 保留所有权利。
Axonal signals are key players in central nervous system myelination. During development, the onset of myelination depends on a balance between positive and negative axonal signals. Among negative signals are inhibitory adhesion molecules that need to be removed from the cell surface for the myelination process to proceed. Positive signals necessary to initiate myelination consist of both interactions with specific adhesion molecules and electrical activity-induced release of promyelinating factors. In multiple sclerosis, demyelination induces major modifications of axonal surface components. The disruption of these factors might participate to the failure of the myelin repair process. (c) 2005 Elsevier B.V. All rights reserved.