Layer-by-Layer Assembled Thin Films and Microcapsules of Nanocrystalline Cellulose for Hydrophobic Drug Delivery
Layer-by-Layer Assembled Thin Films and Microcapsules of Nanocrystalline Cellulose for Hydrophobic Drug Delivery
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DOI：
10.1021/am505681e
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发表时间：
2014-11-26
影响因子：
9.5
通讯作者：
Patil, Satish
中科院分区：
文献类型：
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作者：
Mohanta, Vaishakhi;Madras, Giridhar;Patil, Satish
一层一层（LbL）的方法已被用于制造的多层薄膜和微胶囊具有纳米纤维形态，使用纳米晶体纤维素（NCC）作为组件的一个组成部分。这些纳米组装体作为药物递送载体的适用性已经通过装载抗癌药物盐酸多柔比星和水不溶性药物姜黄素进行了探索。具有良好水溶性的盐酸阿霉素后负载在组装体中。在姜黄素的情况下，其是非常疏水的并且在水中具有有限的溶解度，在掺入LbL组装体之前，通过与NCC的非共价相互作用制备稳定的分散体。考虑到NCC是疏水性药物的通用载体，通过分子对接的方法对其他亲脂性药物与NCC的相互作用进行了理论分析。
A layer-by-layer (LbL) approach has been employed for the fabrication of multilayer thin films and microcapsules having nanofibrous morphology using nanocrystalline cellulose (NCC) as one of the components of the assembly. The applicability of these nanoassemblies as drug delivery carriers has been explored by the loading of an anticancer drug, doxorubicin hydrochloride, and a water-insoluble drug, curcumin. Doxorubicin hydrochloride, having a good water solubility, is postloaded in the assembly. In the case of curcumin, which is very hydrophobic and has limited solubility in water, a stable dispersion is prepared via noncovalent interaction with NCC prior to incorporation in the LbL assembly. The interaction of various other lipophilic drugs with NCC was analyzed theoretically by molecular docking in consideration of NCC as a general carrier for hydrophobic drugs.