Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock
Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock
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DOI：
10.1016/s0140-6736(03)14899-4
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发表时间：
2003-11-29
期刊：
影响因子：
168.9
通讯作者：
Annane, D
中科院分区：
文献类型：
--
作者：
Sharshar, T;Gray, F;Annane, D
实验和临床研究结果表明，感染性休克与心血管自主功能衰竭有关。因此，我们的目的是研究感染性休克患者控制心血管系统的大脑自主神经中心是否存在缺血和凋亡。方法在前瞻性队列研究中，我们对19例感染性休克患者、7例非感染性休克患者和5例突然死于颅外损伤的患者进行了视上核、室旁核、杏仁核、蓝斑核和髓自主神经核的尸检检查。对缺血和凋亡的神经元、小胶质细胞、肿瘤坏死因子α (TNFalpha)和诱导型一氧化氮合酶（iNOS）的表达进行评分。各组间缺血、神经元和小胶质细胞凋亡评分差异有统计学意义(p=0.0007
Background Results of experimental and clinical studies have shown that septic shock is associated with cardiovascular autonomic failure. Thus, we aimed to investigate the existence of ischaemia and apoptosis within the cerebral autonomic centres that control the cardiovascular system in patients with septic shock.Methods In a prospective cohort study, we did post-mortem examinations of supraoptic and paraventricular nuclei, cerebral amygdala, locus coeruleus, and medullary autonomic nuclei in 19 patients with septic shock, seven with non-septic shock and five who died suddenly from extracranial injury. Ischaemic and apoptotic neurons and microglial cells, and expression of tumour necrosis factor alpha (TNFalpha) and inducible nitric oxide synthase (iNOS) were scored.Findings Ischaemic, neuronal, and microglial apoptosis scores differed between groups (p=0.0007, p