Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance Imaging
Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance Imaging
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DOI：
10.1161/01.cir.0000129310.17277.e7
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发表时间：
2004-06-15
期刊：
影响因子：
37.8
通讯作者：
Fayad, ZA
中科院分区：
文献类型：
--
作者：
Sirol, M;Itskovich, VV;Fayad, ZA
背景 - 动脉粥样硬化斑块中特定成分的 MRI 可以提供有关斑块稳定性及其破裂可能性的信息。我们使用新的 MR 序列对动脉粥样硬化兔子中的钆氟进行了评估，该序列允许在注射后 1 小时内检测斑块，并评估富含脂质和非富含脂质的斑块的增强情况。方法和结果 - 12 只患有主动脉斑块的兔子和 6 只对照兔子在注射钆氟（50 μmol/kg）之前和注射后 24 小时内接受了 MRI。比较两个 T1 加权、分段梯度回波序列 (TFL)，以增强注射后血管壁轮廓：(1) 反转恢复预脉冲 (IR-TFL) 或 (2) 反转恢复和基于扩散的流动抑制预脉冲的组合 (IR-DIFF-TFL)。注射后1小时使用IR-TFL，由于血流抑制不良，血管壁未勾画出来；注射后24小时，增强率为37%（P<0.01）。 IR-DIFF-TFL 显示对比对比前显着增强（1 小时：164% [ P < 0.005]；24 小时：207% [ P < 0.001]）。注射后 1 小时和 24 小时，使用 IR-DIFF-TFL 的对比噪声比高于 IR-TFL（1 小时：13.0 +/- 7.7 对比 - 19.8 +/- 10.3 [ P < 0.001]；24 小时：15.2 +/- 5.9 对比 11.4 +/- 8.9 [ P = 0.052]）。对照组注射钆氟后血管壁未见强化。组织学切片中的富含脂质的区域与相应 MR 图像中的信号强度之间发现了很强的相关性（r(2) = 0.87；P < 0.001）。这表明钆氟对富含脂质的斑块具有高亲和力。结论 - 钆氟增强 MRI 改善了动脉粥样硬化斑块的检测。 IR-DIFF-TFL 方法可以在注射钆氟后 1 小时内早期检测动脉粥样硬化斑块。
Background - MRI of specific components in atherosclerotic plaque may provide information on plaque stability and its potential to rupture. We evaluated gadofluorine in atherosclerotic rabbits using a new MR sequence that allows plaque detection within 1 hour after injection and assessed enhancement in lipid-rich and non - lipid-rich plaques.Methods and Results - Twelve rabbits with aortic plaque and 6 controls underwent MRI before and up to 24 hours after gadofluorine injection (50 mumol/kg). Two T1-weighted, segmented gradient-echo sequences (TFL) were compared to enhance vessel wall delineation after injection: ( 1) an inversion-recovery prepulse (IR-TFL) or ( 2) a combination of inversion-recovery and diffusion-based flow suppression prepulses (IR-DIFF-TFL). With the use of IR-TFL at 1 hour after injection, the vessel wall was not delineated because of poor flow suppression; at 24 hours after injection, the enhancement was 37% ( P < 0.01). IR-DIFF-TFL showed significant enhancement after versus before contrast ( 1 hour: 164% [ P < 0.005]; 24 hours: 207% [ P < 0.001]). At 1 hour and 24 hours after injection, the contrast-to-noise ratio was higher with the use of IR-DIFF-TFL than with IR-TFL ( 1 hour: 13.0 +/- 7.7 versus - 19.8 +/- 10.3 [ P < 0.001]; 24 hours: 15.2 +/- 5.9 versus 11.4 +/- 8.9, respectively [ P = 0.052]). There was no enhancement in the vessel wall after gadofluorine injection in the control group. A strong correlation was found (r(2) = 0.87; P < 0.001) between the lipid-rich areas in histological sections and signal intensity in corresponding MR images. This suggests a high affinity of gadofluorine for lipid-rich plaques.Conclusions - Gadofluorine-enhanced MRI improves atherosclerotic plaque detection. The IR-DIFF-TFL method allows early detection of atherosclerotic plaque within 1 hour after gadofluorine injection.