Injectable thermo-responsive hydrogel composed of xanthan gum and methylcellulose double networks with shear-thinning property
Injectable thermo-responsive hydrogel composed of xanthan gum and methylcellulose double networks with shear-thinning property
复制标题
由黄原胶和甲基纤维素双网络组成的具有剪切稀化特性的可注射热响应水凝胶
DOI：
10.1016/j.carbpol.2015.06.013
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发表时间：
2015-11-05
影响因子：
11.2
通讯作者：
Yao, Ping
中科院分区：
文献类型：
--
作者：
Liu, Zhijia;Yao, Ping
将黄原胶（XG）和甲基纤维素（MC）在水溶液中物理共混，制备了可注射的水凝胶前体溶液。由于XG/MC共混物形成了由XG双螺旋链结构组成的XG网络，因此在室温下是一种具有良好剪切变稀性能的高粘度溶液。当温度从23 ℃变化到37 ℃时，热响应MC网络形成，这导致XG/MC共混溶液凝胶化。共混物的胶凝时间和储能模量可以通过XG和/或MC浓度来调节。体外和体内研究均表明，使用注射器注射后，共混溶液立即恢复其高粘度，并在体温下快速形成水凝胶。通过将水凝胶植入大鼠体内，验证了水凝胶的体内生物相容性和生物降解性。体外研究表明，XG/MC共混物是一种有前途的可注射水凝胶材料，可用于长期给药。(C)2015爱思唯尔有限公司版权所有。
Injectable hydrogel precursor solution was prepared by physical blend of xanthan gum (XG) and methylcellulose (MC) in aqueous solution. Due to the formation of XG network composed of XG double helical strand structure, XG/MC blend was a high viscous solution with good shear-thinning property at room temperature. When the temperature was changed from 23 to 37 degrees C, thermo-responsive MC network formed, which caused XG/MC blend solution to gelate. The gelation time and storage modulus of the blend can be tuned by XG and/or MC concentrations. Both in vitro and in vivo investigations revealed that the blend solution immediately recovered its high viscosity and rapidly formed hydrogel at body temperature after injection using a syringe. In vivo biocompatibility and biodegradability of the hydrogel were validated by implantation of the hydrogel in rats. In vitro investigation demonstrated that XG/MC blend is a promising injectable hydrogel material for long-term drug delivery. (C) 2015 Elsevier Ltd. All rights reserved.