Schlemm's canal and trabecular meshwork morphology in high myopia
Schlemm's canal and trabecular meshwork morphology in high myopia
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DOI：
10.1111/opo.12451
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发表时间：
2018-05-01
影响因子：
2.9
通讯作者：
Wang, Junming
中科院分区：
文献类型：
--
作者：
Chen, Zhiqi;Song, Yinwei;Wang, Junming
目的：近视者患开角型青光眼的风险较高，但其原因尚不清楚。本研究旨在探讨高度近视眼Schlemm氏管和小梁网大小的形态学改变。采用光学相干断层扫描（OCT）对Schlemm管和小梁网大小进行成像。结果高度近视组鼻侧Schlemm管直径明显大于对照组，鼻侧Schlemm管直径大于对照组，鼻侧Schlemm管直径大于对照组，眼轴长度小于对照组，眼轴长度小于对照组（188.185.6m vs 127.4 +/- 46.7m，P0.05），而施累姆氏管面积与眼内压呈显著负相关结论本研究首次报道高度近视眼Schlemm管直径和面积增大，小梁网厚度减小，有助于了解高度近视眼与开角型青光眼的密切关系。通过OCT图像分析Schlemm管和小梁网可能有助于揭示高度近视的潜在病理生理机制。
PurposeMyopes have a higher risk for open-angle glaucoma; however, the reason is not clear. This study aims to explore the morphologic alterations of Schlemm's canal and trabecular meshwork size in highly myopic eyes.MethodsForty myopic eyes from 40 patients with high myopia and 40 control eyes from 40 subjects with low myopia, emmetropia or low hyperopia were enrolled. Optical coherence tomography (OCT) was used to image Schlemm's canal and trabecular meshwork size. The correlations between the morphological alterations of Schlemm's canal and trabecular meshwork, spherical equivalent refractive error, axial length, and intraocular pressure were analysed.ResultsSubjects with high myopia had a significantly larger Schlemm's canal diameter in the nasal (188.185.6m vs 127.4 +/- 46.7m, P0.05), while Schlemm's canal area showed a significant negative correlation with intraocular pressure (r=-0.33, P=0.039).ConclusionsThis study reports for the first time that eyes with high myopia have a larger Schlemm's canal diameter and area, as well as decreased trabecular meshwork thickness, which may help to understand the close association between high myopia and open-angle glaucoma. Schlemm's canal and trabecular meshwork analysis by OCT images may help to characterise the underlying pathophysiological mechanisms involved in high myopia.