Exercise-Associated Changes in the Corticosterone Response to Acute Restraint Stress: Evidence for Increased Adrenal Sensitivity and Reduced Corticosterone Response Duration
Exercise-Associated Changes in the Corticosterone Response to Acute Restraint Stress: Evidence for Increased Adrenal Sensitivity and Reduced Corticosterone Response Duration
复制标题
DOI：
10.1038/npp.2013.329
复制
发表时间：
2014-04-01
影响因子：
7.6
通讯作者：
Falls, William A.
中科院分区：
文献类型：
--
作者：
Hare, Brendan D.;Beierle, Jacob A.;Falls, William A.
运动促进抗压能力，并与人类和动物模型中的焦虑和抑郁减少有关。尽管下丘脑-垂体-肾上腺（HPA）轴功能障碍与焦虑和抑郁障碍密切相关，但运动如何改变HPA轴功能的证据是混合的。在这里，我们证明了4周的自愿轮运行是抗焦虑的C57 BL/6 J小鼠，并导致在较短的时间内达到峰值皮质酮（CORT）和更快的衰减CORT后约束压力。在全身给予促肾上腺皮质激素后，轮跑也与肾上腺大小增加和CORT升高相关。最后，HPA轴对外周或脑室内给予地塞米松的反应并不表明车轮运行通过GR介导的机制增加HPA轴负反馈。总之，这些研究结果表明，运动可能会促进压力弹性的一部分，通过确保更快速和缩短HPA反应的压力源，从而影响整体暴露于更持久的HPA轴激活的潜在负面影响。
Exercise promotes stress resistance and is associated with reduced anxiety and reduced depression in both humans and in animal models. Despite the fact that dysfunction within the hypothalamic pituitary adrenal (HPA) axis is strongly linked to both anxiety and depressive disorders, the evidence is mixed as to how exercise alters the function of the HPA axis. Here we demonstrate that 4 weeks of voluntary wheel running was anxiolytic in C57BL/6J mice and resulted in a shorter time to peak corticosterone (CORT) and a more rapid decay of CORT following restraint stress. Wheel running was also associated with increased adrenal size and elevated CORT following systemic administration of adrenocorticotropic hormone. Finally, the HPA-axis response to peripheral or intracerebroventricular administration of dexamethasone did not suggest that wheel running increases HPA-axis negative feedback through GR-mediated mechanisms. Together these findings suggest that exercise may promote stress resilience in part by insuring a more rapid and shortened HPA response to a stressor thus affecting overall exposure to the potentially negative effects of more sustained HPA-axis activation.