Are choriocapillaris flow void features robust to diurnal variations? A swept-source optical coherence tomography angiography (OCTA) study
Are choriocapillaris flow void features robust to diurnal variations? A swept-source optical coherence tomography angiography (OCTA) study
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DOI：
10.1038/s41598-020-68204-x
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发表时间：
2020-07-09
影响因子：
4.6
通讯作者：
Chua, Jacqueline
中科院分区：
文献类型：
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作者：
Lin, Emily;Ke, Mengyuan;Chua, Jacqueline
我们使用扫描源光学相干断层扫描血管造影机(SS-OCTA；PLEX Elite 9000，Carl Zeiss Meditec，Inc.，Carl Zeiss Meditec，Inc.，美国都柏林)评估了日变化对脉络膜和视网膜微血管和结构测量的影响。14名没有眼部疾病的参与者接受了SS-OCTA成像，使用3x3 mm(2)黄斑扫描模式，在两天的五个时间点。生成脉络膜毛细血管流空，以确定其密度(百分比)、大小(µm)和数量。视网膜血管造影显示浅层大血管、浅层和深层血管丛毛细血管的灌流密度。手动测量中心凹下脉络膜厚度和视网膜厚度。重复测量的方差分析被用来研究昼夜变化对脉络膜和视网膜测量的影响。在密度、大小和数量方面，没有观察到任何流动空洞特征的日变化规律。脉络膜厚度有明显的昼夜变化规律，白天呈递减趋势(P
We evaluated the impact of diurnal variation on choroidal and retinal microvasculature and structural measurements using a swept-source optical coherence tomography angiography machine (SS-OCTA; PLEX Elite 9,000, Carl Zeiss Meditec, Inc., Dublin, USA). Fourteen participants who were without ocular diseases underwent SS-OCTA imaging using 3x3-mm(2) macular scan pattern on two separate days at five time points. Choriocapillaris flow voids were generated to determine its density (percentage), size (mu m) and numbers. Perfusion densities of the large superficial vessels, as well as capillaries on superficial and deep vascular plexuses were generated from retinal angiograms. Subfoveal choroidal and retinal thicknesses were manually measured. Repeated-measures ANOVA was used to investigate the impact of diurnal variation on choroidal and retinal measurements. There was no observable diurnal pattern for any of the flow void features, in terms of the density, size and numbers. There was a significant diurnal pattern observed in the choroidal thickness, where it decreased progressively during the day (P