Organometallic Processes in Water
Organometallic Processes in Water
复制标题
DOI：
10.1007/3418_2018_17
复制
发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Lipshutz, Bruce H.
中科院分区：
文献类型：
--
作者：
Gallou, Fabrice;Lipshutz, Bruce H.
在我们寻找reprotoplasty极性非质子溶剂的可持续替代品的过程中，确定了表面活性剂技术的高影响力和长期潜力。基于水胶束催化，已经开发了各种合成方法，并在规模上实施，这些方法依赖于各种过渡金属催化的转化，以及也适合于这种水中化学的其他反应类型。实施通常会在我们的整个产品组合中带来显著的效益;也就是说，除了环境效益外，从经济和生产力的角度来看，还可以实现进步。代表性的益处包括有机溶剂消耗、水使用和循环时间的减少、更温和的反应条件以及改进的产率和选择性，这些都有助于改进的工艺性能和更低的制造成本。使用催化量的非离子设计表面活性剂（例如，TPGS-750-M）在水和精心选择的有机助溶剂中，而不是传统的和不需要的有机溶剂中。在我们在该领域的努力过程中获得的进一步的机理洞察力使我们开发了新的和总是更有效的催化体系，具有均相和非均相性质，特别是为介质量身定制的。更有吸引力的协同效应的潜力已得到明确证明。总的来说，这些进展为整体转型铺平了道路，但对环境负责，催化方法。
During our search for sustainable alternatives for reprotoxic polar aprotic solvents, the high-impact and long-term potential of surfactant technology was identified. Based on aqueous micellar catalysis, various synthetic methodologies have been developed and implemented on scale that rely on a variety of transition-metal-catalyzed transformations, as well as other reaction types that are also amenable to this chemistry in water. Implementation typically results in significant benefits across our entire portfolio; that is, in addition to the environmental benefits, from the economic and productivity perspectives, there are also advances to be realized. Representative benefits include reduction in organic solvent consumption, water use, and cycle time, milder reaction conditions, and improved yields and selectivities, which all contribute to improved process performance and lower manufacturing costs.These surfactant-enabled reactions can be upscaled in the already existing multipurpose facilities of pharmaceutical or other chemical organizations, using a catalytic amount of a combination of a nonionic designer surfactant (e.g., TPGS-750-M) in water and a well-chosen organic cosolvent, instead of traditional and undesirable organic solvents.Further mechanistic insight gained in the course of our efforts in the field led us to the development of new and always more effective catalytic systems, of both a homogeneous and heterogeneous nature, specifically tailor-made for the medium. The potential of even more appealing synergistic effects has been clearly demonstrated. Taken together, these advances pave the way for an overall transformational, and yet environmentally responsible, approach to catalysis.