ABNORMAL SERUM IGG SUBCLASS PATTERN IN CHILDREN WITH DOWNS-SYNDROME
ABNORMAL SERUM IGG SUBCLASS PATTERN IN CHILDREN WITH DOWNS-SYNDROME
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DOI：
10.1136/adc.67.5.628
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发表时间：
1992-05-01
影响因子：
5.2
通讯作者：
NORDVALL, SL
中科院分区：
文献类型：
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作者：
ANNEREN, G;MAGNUSSON, CGM;NORDVALL, SL
易受感染是唐氏综合症的一个众所周知的特征。在 38 名 1-12 岁唐氏综合症儿童中研究了这种倾向与 IgG 亚类血清浓度之间的可能关系。年龄匹配的 50 名健康儿童作为对照组。在所研究的所有三个年龄组（即 1-2.5、4-8 和 9-12 岁）中，唐氏综合症儿童的血清 IgG1 和 IgG3 浓度均显着升高。前两组的血清IgG2浓度正常，但第三组的血清IgG2浓度显着降低。相比之下，唐氏综合症儿童的 IgG4 浓度在所有三个年龄组中均显着降低。此外，在 4-12 岁的唐氏综合症儿童中，68% (15/22) 的 IgG4 浓度低于对照几何平均值的 2 个标准差。该结果可能部分解释了患有唐氏综合症的儿童容易感染有荚膜细菌的情况。尽管这些异常的根本原因尚不清楚，但 IgG 亚类测定似乎与唐氏综合症儿童的临床评估相关。
Susceptibility to infections is a well known feature of Down's syndrome. The possible relation between this predisposition and the serum concentrations of the IgG subclasses was studied in 38 children with Down's syndrome aged 1-12 years. An age matched group of 50 healthy children served as controls. The serum concentrations of IgG1 and IgG3 were significantly raised among children with Down's syndrome in all three age groups studied (that is 1-2.5, 4-8, and 9-12 years). The serum concentrations of IgG2 were normal in the first two groups but significantly reduced in the third age group. In contrast, the concentrations of IgG4 among children with Down's syndrome were significantly reduced in all three age groups. Moreover, among the children with Down's syndrome aged 4-12 years 68% (15/22) had IgG4 concentrations below 2 SDs of the geometrical mean of the controls. The results may partially explain the proneness of children with Down's syndrome to infections with encapsulated bacteria. Although the underlying cause of these abnormalities is unknown, IgG subclass determination seems relevant in the clinical evaluation of children with Down's syndrome.